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Table 1 Genes with synthetic slow growth or synthetic lethal interactions with tra1SRR 3413

From: Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes

GENE 1

Orf

SSL2

GO3

Location, component4

phenotype5

stress6

#7

MCK1

YNL307C

SL

1, 3

cytoplasm, nucleus

 

X

28

CDC73

YLR418C

s

1, 3, 10

Cdc73/Paf complex, nucleus

T, R

X

159

CSE2

YNR010W

S

1, 3, 10

mediator complex

R

X

19

HTZ1

YOL012C

S

1, 3, 10

nucleus

  

186

LEO1

YOR123C

s

1, 3, 10

Cdc73/Paf complex, nucleus

T

 

39

RAD52

YML032C

s

1, 3, 10

nucleus

 

X

196

SPT8

YLR055C

s

1, 3, 10

SAGA complex, nucleus

  

62

SRB2

YHR041C

s

1, 3, 10

Srb-mediator complex

T, E

 

34

SWR1

YDR334W

s

1, 3, 10

SWR1 complex, nucleus

R

 

112

VPS71

YML041C

s

1, 3, 10, 9

SWR1 complex, nucleus

E

 

97

VPS72

YDR485C

s

1, 3, 10, 9

SWR1 complex, nucleus

E

 

87

KAR3

YPR141C

s

1, 3, 7

microtubule, spindle pole body

E

 

131

UBI4

YLL039C

s

1, 3, 8, 9

cytoplasm

 

X

7

UBP15

YMR304W

s

1, 3, 8, 9

cytoplasm

  

0

SWC3

YAL011W

s

1, 3, 9, 10

SWR1 complex, nucleus, mitochondrion

  

85

DOA1

YKL213C

s

1, 9, 8

cytoplasm, nucleus

 

X

26

TOR1

YJR066W

S

1,2,3,4,5,6,7,8,9,10

cellular membranes

R

X

27

CKB2

YOR039W

s

1,2,3,4,5,7,8,9,10

protein kinase CK2, CURI complex

 

X

14

SNF1

YDR477W

s

1,3,4,5,6,7,8,9,10

cytoplasm, nucleus, nuclear evelope, mitochondrion, vacuole

R

X

18

SNF4

YGL115W

S

1,3,4,5,6,7,8,9,10

cytoplasm, nucleus, nuclear envelope, PM

  

7

CNB1

YKL190W

s

1,3,4,5,7,9,10

calcineurin complex

 

X

48

EOS1

YNL080C

S

1,3,4,7

ER membrane

 

X

4

SIS2

YKR072C

s

1,3,5,10

cytoplasm, nucleus

 

X

10

NUM1

YDR150W

s

1,3,7,9

cell cortex, cellular bud tip, mitochondrion

  

57

SWI4

YER111C

s

1, 3, 7, 10

nucleus

CW

 

69

UBP6

YFR010W

S

1,3,8,9,10

proteosome

 

X

28

MSC1

YML128C

s

1,3,9,6

ER, mitochondrion

R

 

14

ARP6

YLR085C

s

10, 1, 2

SWR1 complex, cytoplasm

R

 

149

CAF40

YNL288W

s

2, 10

CCR4-NOT complex

R

 

8

NST1

YNL091W

s

2, 10

cytoplasm

 

X

2

PUB1

YNL016W

s

2, 10

cytoplasm, nucleus, hnRNP complex

 

X

5

PIH1

YHR034C

s

2, 3, 8, 10

cytoplasm, nucleus, snRNP complex

  

2

HMT1

YBR034C

s

2, 4 10

nucleus

  

4

PML39

YML107C

SL

2, 4, 10

nuclear pore, ribosome

  

4

HCR1

YLR192C

s

2, 8

translation IF3 complex

T

X

5

PPQ1

YPL179W

S

2, 8

cytoplasm

  

0

TMA23

YMR269W

s

2, 8

nucleolus, ribosome

  

5

RRP6

YOR001W

SL

2, 8, 10

nuclear exosome (RNase complex)

  

16

SKY1

YMR216C

s

2,3,4,8,10

cytoplasm

  

5

STP1

YDR463W

s

2,4,7,8,10

nucleus

  

2

KNS1

YLL019C

SL

3

  

X

0

BIM1

YER016W

s

3, 1, 7

cytoplasm, microtubule, kinetochore, spindle pole body

  

282

NBP2

YDR162C

s

3, 7

cytoplasm, nucleus

CW, R

X

49

PRB1

YEL060C

s

3, 8, 9

vacuole

 

X

3

SEL1

YML013W

s

3, 8, 9

ubiquitin ligase complex, ER, mitochondrion

  

3

TPS2

YDR074W

s

3,5,7,8,10

mitochondrion

 

X

4

ITR1

YDR497C

s

4, 5, 7, 9

plasma membrane

 

X

9

NEW1

YPL226W

s

4, 5, 9, 8

cytoplasm, mitochondrion

  

8

AQR2

YBR043C

s

4, 7

plasma membrane

  

1

GTR1

YML121W

s

4, 9

cytoplasm, endosome, nucleus, vacuole

T, E, R

 

5

VAM10

YOR068C

SL

4, 9

vacuolar membrane

  

11

SER1

YOR184W

s

5

cytoplasm

  

1

SER2

YGR208W

s

5

cytoplasm, nucleus

  

5

GCR2

YNL199C

SL

5, 10, 3

nucleus

E

 

30

ARO1

YDR127W

SL

5, 6

cytoplasm

E

 

0

ARO2

YGL148W

SL

5, 6

cytoplasm

  

1

ETR1

YBR026C

s

5, 6

mitochondrion

  

0

LIP2

YLR239C

s

5, 6

mitochondrion

  

7

LIP5

YOR196C

S

5, 6

mitochondrion

  

2

OAR1

YKL055C

s

5, 6

mitochondrion

  

0

ERG3

YLR056W

s

5, 9

ER

  

19

MDM34

YGL219C

S

6

mitochondrial outer membrane

E, R

 

10

KGD2

YDR148C

S

6, 5

mitochondrion

  

0

MDM10

YAL010C

s

6, 9

Mdm10/Mdm12/Mmm1 complex, mitochondrial outer membrane

T, E

 

11

BEM1

YBR200W

S

7, 3, 1

bud neck

E

 

33

BEM4

YPL161C

s

7, 3, 1

cytoplasm, nucleus

T, E

X

29

Smi1

YGR229C

s

7, 3, 1

bud tip, nucleus

T, E, CW, R

 

111

ROM2

YLR371W

SL

7, 3, 9

bud tip

 

X

16

CSF1

YLR087C

s

7, 5, 6

mitochondrion

CW

 

24

ECM30

YLR436C

s

7, 9

cytoplasm

CW

 

1

KRE1

YNL322C

s

7, 9

cell wall

  

64

VIP1

YLR410W

S

7, 9

cytoplasm

  

15

TPM1

YNL079C

S

7,9,3

actin cable

E, CW, R

 

21

RPS27B

YHR021C

S

8

ribosome

T

 

1

RPN4

YDL020C

S

8, 10, 1, 3

nucleus, proteasome

T, E

X

242

YDJ1

YNL064C

S

8, 9, 6

cytosol, microsome

R

X

27

CCZ1

YBR131W

s

9

late endosome, membrane

E, R

X

6

MON1

YGL124C

s

9

cytosol, vacuolar membrane

  

12

VAM3

YOR106W

s

9

vacuolar membrane

R

 

9

VAM7

YGL212W

s

9

vacuolar membrane

T, E, CW, R

 

8

PIB2

YGL023C

s

9, 1, 7

late endosome, mitochondrion

R

 

0

GSG1

YDR108W

s

9, 3

TRAPP complex

 

X

11

 

YDR049W

s

9, 3, 8

cytoplasm, mitochondrion

E, R

  

MEH1

YKR007W

S

9, 4, 5

cytosol, vacuolar membrane

 

X

2

PMR1

YGL167C

s

9, 4, 7

Golgi membrane

E

 

41

AUT7

YBL078C

s

9, 5

autophagic vacuole, cytosol

 

X

2

CCW12

YLR110C

s

9, 7

cell wall

CW

 

13

COG5

YNL051W

S

9, 7

Golgi

  

14

COG6

YNL041C

S

9, 7

Golgi

  

17

COG7

YGL005C

S

9, 7

Golgi

  

12

COG8

YML071C

S

9, 7

Golgi

  

17

DID2

YKR035W

s

9, 7

cytoplasm, late endosome

  

2

GYP1

YOR070C

S

9, 7

Golgi, mitochondrion

R

 

48

MNN10

YDR245W

s

9, 7

α-1,6-mannosyltransferase complex

E, R, CW

 

19

MON2

YNL297C

s

9, 7

cytosol, endosome

R

 

40

RIC1

YLR039C

S

9, 7

Golgi, nucleus

E

 

159

RUD3

YOR216C

s

9, 7

Golgi

  

26

SEC22

YLR268W

s

9, 7

ER, Golgi

CW

 

44

TLG2

YOL018C

s

9, 7

early endosome, trans Golgi

R

 

12

VPS1

YKR001C

S

9, 7

cytoplasm, membrane fraction

  

28

VPS17

YOR132W

s

9, 7

endosome, retromer complex

  

11

VPS38

YLR360W

s

9, 7

Vps34 complex

R

 

12

VPS41

YDR080W

s

9, 7

HOPS complex, vacuolar membrane, endosome

R

 

7

VPS53

YJL029C

SL

9, 7

GARP complex, Golgi, cytoplasm

T, R

 

10

YPT6

YLR262C

s

9, 7

Golgi

E, R

 

181

YPT7

YML001W

s

9, 7

vacuole, mitochondrion

T, R

 

6

 

YLR111W

s

9, 7

 

CW

 

0

GET1

YGL020C

S

9, 8

GET complex, ER, mitochondrion

R

X

284

SSE1

YPL106C

SL

9, 8

cytoplasm

T

 

15

BTS1

YPL069C

S

9,5,6

mitochondrion

CW

 

16

UBP3

YER151C

s

9,7,10,1,3

cytoplasm

R

 

32

 

YDL180W

s

 

vacuole

  

0

 

YEL033W

s

  

T

 

0

 

YOR235W

s

    

0

  1. 1 Genes are placed according to related GO terms with relevant groupings separated by lines.
  2. 2 Phenotype of double mutants. SL, synthetic lethal; S, severe slow growth; s, slow growth (in SC media at 33.5°C). For those underlined the phenotype is most easily detected on YPD at 30C as the single mutant shows reduced growth on SC media
  3. 3 Gene ontology: (1) DNA replication/repair and chromosome stability, (2) RNA processing, (3) cell cycle/microtubule, (4) general transport, (5) metabolism, (6) mitochondria, (7) polarity/cell wall, (8) protein/ribosome biosynthesis, (9) secretion/protein trafficking, (10) transcription, (11) unknown
  4. 4 Cellular compartments and/or components as indicated in the Saccharomyces Genome Database
  5. 5 Relevant phenotypes of single mutants as described in the Saccharomyces Genome Database. E, sensitivity to ethanol; CW, sensitivity to calcofluor white; T, shortened telomeres; R, sensitivity to rapamycin
  6. 6 Annotated in the Saccharomyces Genome Database as involved in stress response or autophagy
  7. 7 Number of previously identified SSL interactions in the Saccharomyces Genome Database
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BMC Genomic Data

ISSN: 2730-6844

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