Fig. 3

Genome browser views of the upstream region of Ednrb. (a) The genomic region in rats (rn5). Four tracks are shown (from the top): (i) RefSeq genes; (ii) the profile of H3K4me1 for the rat liver; (iii) the phastCons conservation score; (iv) the capture target regions. The deletion found upstream of Ednrb in KFRS4/Kyo is indicated by a red rectangle. (b) The corresponding genomic region in humans (hg19). Four groups of tracks are shown (from the top): (i) the positions that correspond to the deleted CNSs in rat; (ii) RefSeq genes (only the orthologous gene between human and rat is shown); (iii) the contact profile generated from Hi-C data of human umbilical vein endothelial cells (HUVEC) and the profiles of H3K4me1, H3K27ac, and DNase I hypersensitive sites for HUVEC; (iv) the contact profile generated from Hi-C data of human mammary epithelial cells (HMEC) and the profiles of H3K4me1, H3K27ac, and DNase I hypersensitive sites for HMEC. The corresponding CNSs that are deleted in rats are connected by gray lines. The anchor position, which contains the transcription start site of Ednrb, is indicated by a dark-colored highlight in the contact profile. The region containing a predicted enhancer is highlighted in pink. A possible three-dimensional interaction between the enhancer and the promoter of Ednrb is indicated by a blue arc