Novel mutations in TLR genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection

Table 2 Missense mutations in the ovine TLR2

		Wild type frequency	Frequency of mutation in heterozygous state	Frequency of mutation in homozygous state
1985A>W	Glu662 [Glu, Val]	0.94 (21%)	0.06 (4.7%)	0
2008A>Y	Phe670 [Leu, Phe]	0.55 (6.5%)	0.25 (25%, *4.5*)	0.20 (7.6%, *1.1*)¹
2012A>M	Lys671 [Asn, Thr]	0.99 (11.4%)	0.01 (0%)	0
2013G>T	Lys671 [Asn, Thr]	0.99 (11.4%)	0	0.01 (0%)
2028G>S	Lys676 [Asn, Lys]	0.99 (11.4%)	0.01 (0%)	0
2037T>Y	Leu679Phe	0.57 (6.3%)	0.35 (19.9%, *2.01*)	0.08 (10.3%, *1.36*)
2038G>A	Val680Ile	0.998(11.4%)	0	0.002 (0%)
2040C>T	Val680Ile	0.998(11.4%)	0	0.002 (0%)
2090G>R	Arg697 [His, Arg]	0.997 (12.9%)	0.001 (0%)	0.003 (0%)
2111C>y	Ser704 [Ser, Leu]	0.998 (11.4%)	0.002 (0%)	0
2117G>A	Ser706Asn	0.995 (11.4%)	0	0.005 (0%)
2126G>A	Arg709Lys	0.997 (11.4%)	0	0.003 (0%)
2233G>R	Val745 [Ile, Val]	0.995 (11.4%)	0.001 (0%)	0.004 (0%)
2276G>A	Arg759Lys	0.995 (11.4%)	0	0.005 (0%)
2296G>A	Val766Thr	0.998 (11.4%)	0	0.002 (0%)
2297T>C	Val766Thr	0.998 (11.4%)	0	0.002 (0%)

¹ The first value in the parenthesis indicate the percentage of animals infected with MAP that carries given point mutation, the second value (bold-italics) is the Odd's ratio (OR) indicating the possible linkage between the point mutation and increased susceptibility to MAP infection.

ISSN: 2730-6844