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Table 4 Prostate cancer susceptibility stratified by Gleason score, T-stage, and serum PSA levels at diagnosis (control vs. SPCa)

From: Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men

Genotype Gleason score ≤ 7
(N = 241)
Gleason score ≥ 8
(N = 150)
  OR* 95% CI p value OR* 95% CI p value
rs1447295       
CC 1.0 reference   1.0 reference  
CA 1.62 1.08 – 2.42 0.02 1.48 0.94 – 2.34 0.09
AA 1.09 0.46 – 2.56 0.84 1.63 0.66 – 3.92 0.29
CA + AA 1.53 1.04 – 2.25 0.03 1.50 0.97 – 2.32 0.07
rs6983267       
TT 1.0 reference   1.0 reference  
TG 0.93 0.62 – 1.39 0.73 0.90 0.57 – 1.42 0.66
GG 1.84 0.96 – 3.55 0.07 2.41 1.20 – 4.86 0.01
TG + GG 1.05 0.72 – 1.55 0.79 1.10 0.72 – 1.69 0.67
Genotype   T1 or T2
(N = 167)
   T3 or T4
(N = 224)
 
  OR* 95% CI p value OR* 95% CI p value
rs1447295       
CC 1.0 reference   1.0 reference  
CA 1.39 0.88 – 2.17 0.15 1.70 1.14 – 2.56 0.01
AA 1.34 0.53 – 3.29 0.53 1.28 0.55 – 2.95 0.57
CA + AA 1.38 0.90 – 2.11 0.14 1.64 1.11 – 2.41 0.01
rs6983267       
TT 1.0 reference   1.0 reference  
TG 0.96 0.61 – 1.51 0.87 0.91 0.61 – 1.36 0.65
GG 2.68 1.37 – 5.30 4.0 × 10-3 1.69 0.87 – 3.31 0.12
TG + GG 1.19 0.78 – 1.83 0.42 1.02 0.69 – 1.49 0.93
Genotype   PSA < 20 ng/mL
(N = 208)
   PSA ≥ 20 ng/mL
(N = 183)
 
  OR* 95% CI p value OR* 95% CI p value
rs1447295       
CC 1.0 reference   1.0 reference  
CA 1.46 0.95 – 2.23 0.08 1.71 1.12 – 2.60 0.01
AA 0.97 0.37 – 2.44 0.95 1.69 0.74 – 3.83 0.21
CA + AA 1.38 0.92 – 2.08 0.12 1.70 1.14 – 2.54 9.0 × 10-3
rs6983267       
TT 1.0 reference   1.0 reference  
TG 0.96 0.63 – 1.47 0.86 0.92 0.60 – 1.40 0.69
GG 1.46 0.72 – 2.96 0.30 2.74 1.45 – 5.24 2.0 × 10-3
TG + GG 1.03 0.69 – 1.55 0.88 1.16 0.78 – 1.73 0.47
Genotype   Nonaggressive
(N = 99)
   Aggressivea
(N = 292)
 
  OR* 95% CI p value OR* 95% CI p value
rs1447295       
CC 1.0 reference   1.0 reference  
CA 1.69 0.98 – 2.91 0.06 1.54 1.06 – 2.25 0.02
AA 1.39 0.44 – 3.99 0.56 1.28 0.59 – 2.81 0.53
CA + AA 1.64 0.97 – 2.75 0.06 1.50 1.05 – 2.15 0.03
rs6983267       
TT 1.0 reference   1.0 reference  
TG 0.99 0.58 – 1.71 0.97 0.93 0.64 – 1.36 0.72
GG 1.45 0.58 – 3.46 0.42 2.32 1.29 – 4.26 0.01
TG + GG 1.05 0.63 – 1.78 0.85 1.12 0.79 – 1.60 0.52
  1. OR*, Age-adjusted odds ratio.
  2. a Aggressive, Gleason score ≥ 8, and/or T-stage T3 or T4, and/or PSA ≥ 20 ng/mL.