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Table 2 Type I error of three models via 1500 simulations at α = 0.05

From: Regression-based approach for testing the association between multi-region haplotype configuration and complex trait

Sample Size Minor Allele Model Type
   hapcc htr HAPGLM
50 q = 0.1 0.097(0.079-0.117) 0.048(0.036-0.063) 0.048(0.036-0.063)
  q = 0.3 0.032(0.022-0.045) 0.039(0.028-0.053) 0.044(0.032-0.059)
  q = 0.5 0.029(0.020-0.041) 0.041(0.030-0.055) 0.047(0.042-0.071)
100 q = 0.1 0.036(0.025-0.049) 0.035(0.024-0.048) 0.047(0.035-0.062)
  q = 0.3 0.031(0.021-0.044) 0.072(0.057-0.090) 0.043(0.031-0.057)
  q = 0.5 0.042(0.030-0.056) 0.047(0.035-0.062) 0.051(0.038-0.067)
200 q = 0.1 0.031(0.021-0.044) 0.026(0.017-0.038) 0.055(0.042-0.071)
  q = 0.3 0.051(0.038-0.067) 0.033(0.023-0.046) 0.047(0.035-0.062)
  q = 0.5 0.040(0.029-0.054) 0.067(0.052-0.084) 0.037(0.026-0.051)
400 q = 0.1 0.035(0.024-0.048) 0.037(0.026-0.051) 0.042(0.030-0.056)
  q = 0.3 0.047(0.035-0.062) 0.028(0.019-0.040) 0.041(0.030-0.055)
  q = 0.5 0.028(0.019-0.040) 0.041(0.030-0.055) 0.042(0.030-0.056)