Interethnic diversity of NAT2 polymorphisms in Brazilian admixed populations

BMC Genomic Data

Table 2 Genotypic and allelic frequency of NAT2 gene in different ethnic groups.

NAT2 SNP	Total	Afro-Brazilians	χ ²	p ¹	Whites	χ ²	p ²	Amerindians	χ ²	p ³
*G191A*
GG	158	104			23			27
GA	22	20	1.075	0.5842	4	1.781	0.4104	3	1.207	0.547
AA	3	1			1			0
G	28	228	0.202	0.6593	50	1.322	0.2471	57	0.942	0.3061
A	338	22			6			3
*C481T*
CC	72	41			11			12
CT	79	60	2.565	0.2774	15	4.836	0.089	10	2.36	0.3073
TT	31	23			2			8
C	223	142	1.466	0.2221	37	1.079	0.2982	34	0.007	0.9338
T	141	106			19			26
*G590A*
GG	92	77			19			10
GA	67	46	1.298	0.5224	8	4.312	0.1158	14	9.943	*0.0069* ^b
AA	24	2			1			6
G	251	200	0.005	0.9405	46	4.661	*0.0288* ^a	34	8.4	*0.0053* ^c
A	115	50			10			26
*A803G*
AA	107	64			15			17
AG	73	61	3.662	0.1603	11	1.333	0.5135	12	0.954	0.6207
GG	3	0			2			1
A	287	189	1.686	0.1836	41	0.117	0.7316	46	0.834	0.3538
G	79	61			15			14
*G857A*
GG	129	86			17			24
GA	51	33	0.986	0.6108	10	3.391	0.1835	6	3.244	0.1975
AA	3	6			1			0
G	309	205	0.419	0.524	44	2.750	0.0964	54	2.013	0.1373
A	57	45			12			6

p: Genotype and allelic p-value for each marker, respectively. p¹, p²and p³: Association between Afro-Brazilians × Whites; Whites × Amerindians and Amerindians × Afro-Brazilians, respectively. a, b and c: p-value adjusted (10³ permutations) = 0.06494, 0.006993 and 0.004995, respectively. χ²: Chi-square tests. Significant association is indicated in bold.

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