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Table 3 Comparative positional analysis of identified QTL with serum lipid QTL in humans and mice and the putative candidate genes located on the QTL regions

From: Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs

SSC Traits POS (cM) PCB at peak HCHR QTL in human HCBP Putative candidate genes Mouse strain QTL mouse peak
1 CT* 80 1q1.3 - 1.4 18q21
15q21-22
CT 18q21 [51] LIPC[52], LIPG[53], ACAA2[54], STARD6[55] (B6 × C3H) F2
(B6 × DBA/2) F2
(B6 × CAST/2) F2
(B6 × C3H) F2
18-40cM
18-46cM
18-47cM
18-48cM
1 HDL/LDL** 87 1q1.5-1.6   HDL 15q21 [56], 15q22 [57]   (B6 × 129) F2 2-90 cM
1 LDL*** 82 1q1.3 - 1.4   LDL-ApoB1 18q21.32 [58]    
2 TG 205 2q2.8-2.9 5q23-31 TG 5 q21.3 -q32 [59] STARD4[60]   
2 HDL*# 118 2p1.2- 2q1.2 11q13 HDL 11q12-13 [31] CILP, PBX4 (MRL × SJL) F2
(B6 × C3H) F2
7-10 cM
7-19 cM
3 HDL* 0 3p1.5-p1.4 7q11 HDL
TC
7q11.23 [61]
7q11.23 [62]
FABP1 (NZB × SM) F2
NZO × (SJL × NZO)
(B6 × CAST) F2
5-61.cM
5-69cM
5-72 CM
4 HDL/LDL* 58 4q1.4-1.5 1q22-25 HDL 1q21-23 [63]
1q23-25 [64];
1q24 [65], 1q25 [66]
CYP7A1[67, 68];
FABP5[69]
(B6 × NZB11) F2 1-91 CM
6 CT* 99 6q2.3 - 2.4 1p36.3-36.1 LDL 1q36.31 [63]
1q36.13 [70]
NR1H2
WWOX [71] LDLRAP1
  
6 TG* 66 6q1.1 - 2.1 19q13 LDL,
TG
19 q12 39 cM [72]
19q13.31 [51], [73]
APOE [74]; ANGPTL3   
7 CT, LDL* 70 7q1.4-71.5 15q24-28 LDL 15q26.1 [51] STARD5   
11 TG*# 28 11p1.1 -1.2 13q12 -24 TG and HDL 13q13 [75]    
12 CT** 36 12p1.3-q1.2 17q21-25 CT/HDL 17q24 [76] WIPI1,   
12 LDL* 38    LDL 17q24.2 [65]; 17q25.3 [77] THRA PEMT   
13 LDL* 97 13q3.3 -3.5 3p31-21 LDL 3p25 [72] PCYT1A[78]; B4GALT4[79] (C56BL/6JxDBA/2J) 3-27cM [80]
16 HDL* 81 16q1.4-2.1 5p14 -12 HDL 5p13.3 [81]
5p15.13 [82]
  (PERAxDBA/2) F2
(PERAxI) F2
11-28 cM
11-28 cM
16 HDL/LDL* 47 16q1.3-1.4 5p14 -12 LDL 5p15.33 [64]    
17 TG*# 72 17q2.2-2.3 13q13 TG and HDL 13q13 [75] ACSS, PLTP   
  1. PCB, pig cytogenetic band; HCHR, human chromosome homologous regions; HCBP, human cytogenetic band.
  2. Significance: Significance of the QTL: * significant on a chromosome-wide level with P < 0.05; ** significant on a experiment-wide level with P < 0.05; *** significant on a experiment-wide level with P < 0.01. Human homologous regions of the pig QTL were identified with the pig QTL database. # QTL with imprinting effect.