Average SNP density (SNPs/Kb) in humans and rhesus macaques, comparatively measuring variation in different genomic regions. A). SNPs/Kb is calculated for nucleotides with > = 4x sequence coverage. B). Average SNP density of human and macaque calculated for different sequencing coverages. SNP density based on all macaque samples is shown with the blue line. SNP density with macaque K20 omitted is shown with the green line and SNP densities with other individual animals omitted one-by-one are shown with dashed blue lines. SNP density based on 100% Indian macaques only is shown with the pink dashed line. C). The SNP densities of five genomic regions in human and macaque; D). Human and macaque dN/dS ratios for cSNPs. Error bars in (C) and (D) indicate standard error of mean.