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Table 4 Power for all tests in simulated data of scenario D, no common SNPs effect, effects of RVs are in the different directions

From: Weighted selective collapsing strategy for detecting rare and common variants in genetic association study

OR 1.3 1.6 1.9 2.2 2.5 2.8 3.1
R ind 0.062 0.058 0.089 0.095 0.118 0.129 0.164
R sum 0.054 0.062 0.092 0.083 0.113 0.118 0.158
B ind 0.062 0.06 0.059 0.074 0.085 0.1 0.128
B sum 0.062 0.059 0.065 0.073 0.09 0.101 0.117
R i n d S C 0.09 0.15 0.214 0.221 0.314 0.352 0.395
R s u m S C 0.094 0.151 0.202 0.21 0.335 0.353 0.449
B wSum 0.107 0.096 0.096 0.136 0.179 0.221 0.27
B wOR 0.09 0.126 0.133 0.165 0.211 0.222 0.255
B KML 0.061 0.055 0.054 0.054 0.067 0.067 0.072
B SSU 0.056 0.053 0.052 0.05 0.062 0.062 0.068
B SSUw 0.095 0.126 0.181 0.254 0.314 0.354 0.478
B aSSU 0.086 0.087 0.13 0.138 0.167 0.162 0.229
B aSSUw 0.114 0.145 0.198 0.271 0.311 0.373 0.456
B aSSUOrd 0.113 0.175 0.241 0.289 0.39 0.409 0.566
B aSSUwOrd 0.129 0.2 0.256 0.321 0.385 0.468 0.543
B wSC 0.135 0.148 0.2 0.227 0.297 0.373 0.465
B wSCd 0.134 0.197 0.25 0.34 0.391 0.441 0.558
  1. There is a customized LD structure among common variants and among rare variants.
  2. Randomly selected eight rare variants are causal variants. Others are non-causal variants. Genetic effect parameters OR for eight rare variants are listed in the table. Odds Ratios for another half of rare variants are in different directions. If OR is 2, OddsRatio= ( 2 , 2 , 1 2 , 1 2 , 3 , 3 , 1 3 , 1 3 ) for eight casual rare variants. Notations of tests are defined similarly as those in Table 1.