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Table 1 Power of VC-score tests under different sample sizes

From: A variance component based multi-marker association test using family and unrelated data

Design h2 Significance level (α)
   0.05 1 × 10-5 1 × 10-6
I. 500/3000     
  0.01 0.840 0.355 0.270
  0.02 1 0.855 0.780
  0.03 1 0.985 0.980
II. 750/2000     
  0.01 0.890 0.345 0.235
  0.02 1 0.825 0.725
  0.03 1 0.975 0.970
III. 750a/2000     
  0.01 0.94 0.435 0.335
  0.02 1 0.92 0.880
  0.03 1 1 0.990
  1. Note.—The design column indicates # of families / # of unrelated individuals. Only nuclear families are simulated, with each family having two parents with a mean of two children.
  2. a. 750 families simulated with enriched risk haplotypes.