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Table 2 The total number of de novo deletions inferred (“count”) and the average number of inferred de novo deletions per child (“average”), stratified by case status and cleft type for both discovery methods

From: A genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk

   Controls   Oral clefts   CL   CP   CLP
MD 438 1.12 286 0.61 89 0.64 80 0.62 117 0.59
PennCNV 1,422 3.64 518 1.11 185 1.32 144 1.12 189 0.95
  count average count average count average count average count average
  1. MD: de novo deletions with coverage of at least ten markers inferred by MinimumDistance; PennCNV: de novo deletions with coverage of at least ten markers inferred by PennCNV. CL: cleft lip; CP: cleft palate; CLP: cleft lip and palate. All differences between cleft and control counts are highly significant, assuming independence of deletions (p<10-6 for all MD comparisons, p<10-40 for all PennCNV comparisons).