Table 1 Interaction analysis between vitamin D receptor ( VDR ) and retinoid X receptor-gamma ( RXRG ) polymorphisms in the discovery cohort (1958 British Birth Cohort) using linear regression
Outcome | VDR | RXRG | N in analysis | Interaction | Unadjusted P (adjusted P*) from joint LRT |
|---|---|---|---|---|---|
SNP | SNP | Beta ± SE | |||
Low density lipoprotein cholesterol | rs3847987 | rs283695 | 4,700 | −0.12 ± 0.04 | 1.0x10−5 (0.03) |
rs11574143 | rs283695 | 4,696 | −0.13 ± 0.04 | 2.9x10−5 (0.04) | |
Serum triglycerides | rs11574143 | rs17429123 | 4,843 | 0.13 ± 0.04 | 4.5x10−5 (0.01) |
rs11574143 | rs10918172 | 4,873 | 0.13 ± 0.04 | 5.7x10−5 (0.02) | |
rs3847987 | rs17429123 | 4,849 | 0.12 ± 0.03 | 7.1x10−5 (0.02) | |
rs3847987 | rs10918172 | 4,880 | 0.12 ± 0.03 | 7.5x10−5 (0.05) | |
Waist Hip Ratio | rs2283342 | rs157872 | 5,067 | −0.01 ± 0.002 | 7.7x10−5 (0.04) |