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Table 2 Haplotype diversity analysis of the 32 ADME core genes

From: Increased genetic diversity of ADME genes in African Americans compared with their putative ancestral source populations and implications for Pharmacogenomics

Gene Hd ASW Hd CEU Hd YRI P value of 10000 times resampling
     ASW_CEU ASW_YRI CEU_YRI
ABCB1 0.6853 0.7284 0.6655 0.3221 0.6599 0.1000
ABCC2 0.6151 0.6966 0.6652 0.0238 0.2121 0.2892
ABCG2 0.9678 0.8872 0.9414 0.0000 0.0400 0.0001
CYP1A1 0.4050 0.2184 0.3655 0.0200 0.4900 0.0062
CYP1A2 0.7904 0.4904 0.6999 0.0000 0.0022 0.0000
CYP2A6 0.3781 0.1962 0.4553 0.0200 0.2600 0.0000
CYP2B6 0.8594 0.7722 0.8208 0.0021 0.2014 0.1000
CYP2C19 0.8328 0.6718 0.8701 0.0000 0.1229 0.0000
CYP2C8 0.3333 0.2178 0.3205 0.0800 0.9400 0.0800
CYP2C9 0.2800 0.1009 0.3358 0.0028 0.5000 0.0000
CYP2D6 0.7261 0.7436 0.7233 0.5936 0.9600 0.4799
CYP2E1 0.7009 0.4614 0.7062 0.0000 0.8974 0.0000
CYP3A4 0.4552 0.0578 0.3594 0.0000 0.0285 0.0000
CYP3A5 0.5461 0.1125 0.4932 0.0000 0.2577 0.0000
DPYD 0.4975 0.2847 0.4901 0.0000 0.7000 0.0000
GSTP1 0.5182 0.5415 0.4742 0.4746 0.0912 0.0600
GSTT1 0.4054 0.2178 0.1662 0.0004 0.0000 0.3400
NAT1 0.5198 0.4005 0.5109 0.0035 0.8000 0.0060
NAT2 0.8245 0.6897 0.8673 0.0000 0.0283 0.0000
SLC22A1 0.6034 0.7277 0.5445 0.0040 0.2492 0.0000
SLC22A2 0.2536 0.1619 0.2691 0.1800 0.8000 0.0392
SLC22A6 0.1236 0.0000 0.1278 0.0015 0.9338 0.0001
SLCO1B1 0.7177 0.6446 0.6918 0.1400 0.5753 0.3198
SLCO1B3 0.8954 0.6618 0.9010 0.0000 0.6520 0.0000
SULT1A1 0.1378 0.0685 0.1847 0.1505 0.5000 0.0096
TPMT 0.6124 0.5236 0.5688 0.0375 0.6000 0.2234
UGT1A1 0.7508 0.5671 0.6923 0.0000 0.0049 0.0001
UGT2B7 0.7506 0.6741 0.7337 0.0470 0.8000 0.1000
  1. The haplotype diversity values of 32 ADME core genes in three populations, and the significances of haplotype diversity between each two populations were calculated by 10000 times resampling. More detailed haplotype information of each gene can be found in Additional file 10: Table S3.