Single congenics within regions I to V on mouse Chr 19. (A) Representation of mouse chromosome 19 with centromere on left. Chr 19 of 129/Sv (represented in white), MOLF M19 (green) and MOLF segments (green) on 129/Sv background (white) in single congenic mouse strains. MOLF-derived segments are homozygous for MOLF alleles, represented by the MM genotype. 129-derived homozygous segments are represented by II genotype. Polymorphic SSLP markers between MOLF and 129 (starting at D19Mit32 near the centromere) used for genotyping, are shown on the top. Names of each congenic strain are listed on the left. TGCT incidence of 129/Sv, M19 and congenics are on the right. The five predicted regions (I-V) are aligned with markers and shown at the bottom of the figure. (B) Bar graph represents TGCT incidences of 129, M19 and single congenic strains. *Indicates that TGCT incidence is significantly different from that of 129.