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Table 2 Test for difference in proportion table for sequence sets divided date of isolatiion

From: Investigation of a recent rise of dual amantadine-resistance mutations in the influenza A M2 sequence

 

Pre-2000

 

Nt = 184, NS31 = 171, NS31N = 12

 

AA+S31

AA+S31N

Favors

P-value

10L

6

0

NA

ID

10H

4

0

NA

ID

26F

1

1

NA

ID

27A

0

2

NA

ID

27T

0

1

NA

ID

27S

0

0

NA

ID

27I

21

0

NA

0.1

28I

71

11

S31N

<0.001

30T

0

0

NA

ID

34E

0

0

NA

ID

 

2000-2010

 

Nt = 560, NS31 = 401, NS31N = 157

 

AA+S31

AA+S31N

Favors

P-value

10L

31

9

NA

0.2

10H

13

7

NA

0.24

26F

2

5

NA

ID

27A

11

7

NA

0.15

27T

8

0

NA

ID

27S

2

0

NA

ID

27I

69

4

S31

<0.001

28I

154

57

NA

0.32

30T

1

0

NA

ID

34E

0

0

NA

ID

 

2010-present

 

Nt = 373, NS31=151, NS31N = 222

 

AA+S31

AA+S31N

Favors

P-value

10L

8

13

NA

0.41

10H

8

8

NA

0.21

26F

0

3

NA

ID

27A

0

29

S31N

<0.001

27T

33

0

S31

<0.001

27S

0

0

NA

ID

27I

33

4

S31

<0.001

28I

73

133

S31N

<0.05

30T

0

0

NA

ID

34E

0

0

NA

ID

  1. The amino acids of interest are included in the left column. The 'AA+S31' column is the count of amino acids in the left column that occur in conjunction with S31 (WT). The 'AA+S31N' column is the count of amino acids in the left column that occur in conjunction with S31N. The 'Favors' column indicates the amino acid, S31 or S31N, with which the amino acid in the left column occurs more often then expected, according the test for difference in proportions. The 'P-value' column gives the p-value of each test for difference in proportion. ID: insufficient data (<10 samples of the AA).