| Pre-2000 | |||
---|---|---|---|---|
 | Nt = 184, NS31 = 171, NS31N = 12 | |||
 | AA+S31 | AA+S31N | Favors | P-value |
10L | 6 | 0 | NA | ID |
10H | 4 | 0 | NA | ID |
26F | 1 | 1 | NA | ID |
27A | 0 | 2 | NA | ID |
27T | 0 | 1 | NA | ID |
27S | 0 | 0 | NA | ID |
27I | 21 | 0 | NA | 0.1 |
28I | 71 | 11 | S31N | <0.001 |
30T | 0 | 0 | NA | ID |
34E | 0 | 0 | NA | ID |
 | 2000-2010 | |||
 | Nt = 560, NS31 = 401, NS31N = 157 | |||
 | AA+S31 | AA+S31N | Favors | P-value |
10L | 31 | 9 | NA | 0.2 |
10H | 13 | 7 | NA | 0.24 |
26F | 2 | 5 | NA | ID |
27A | 11 | 7 | NA | 0.15 |
27T | 8 | 0 | NA | ID |
27S | 2 | 0 | NA | ID |
27I | 69 | 4 | S31 | <0.001 |
28I | 154 | 57 | NA | 0.32 |
30T | 1 | 0 | NA | ID |
34E | 0 | 0 | NA | ID |
 | 2010-present | |||
 | Nt = 373, NS31=151, NS31N = 222 | |||
 | AA+S31 | AA+S31N | Favors | P-value |
10L | 8 | 13 | NA | 0.41 |
10H | 8 | 8 | NA | 0.21 |
26F | 0 | 3 | NA | ID |
27A | 0 | 29 | S31N | <0.001 |
27T | 33 | 0 | S31 | <0.001 |
27S | 0 | 0 | NA | ID |
27I | 33 | 4 | S31 | <0.001 |
28I | 73 | 133 | S31N | <0.05 |
30T | 0 | 0 | NA | ID |
34E | 0 | 0 | NA | ID |