Comparison of the genomic sequence upstream of the human and mouse OPA1 gene. The transcribed sequence is shown in capital letters. Asterisk indicates the 5' limit found by RACE-PCR and highlighted in grey is the conserved sequence that may represent the actual 5' end of the mRNA. The initiation codon for translation (ATG) is in bold. Putative binding sites conserved between human and mouse as identified by computer searches are shown with horizontal bars on top of the sequence line.