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Table 1 Segregation Analysis Results for Three Age-at-onset Traits. Recessive Trait Parameter Estimates (S.E.) from Proportional Hazards Models(GAP) and Regressive Threshold Models (REGRESS)

From: Using an age-at-onset phenotype with interval censoring to compare methods of segregation and linkage analysis in a candidate region for elevated systolic blood pressure

 

Parameter

 

Two Covariates

Five Covariates

Model

UpperA

Mid-pointB

LowerC

UpperA

Mid-pointB

LowerC

Proportional Hazards

      

   Allele Frequency

0.76(.05)

0.78(.05)

0.81(.05)

   

   Major GeneD

1.40(.13)

1.41(.14)

1.37(.15)

   

   SexE

0.23(.07)

0.23(.06)

0.22(.06)

   

   CohortF

0.52(.07)

0.52(.06)

0.53(.06)

   

-logL

6728

6764

6867

   

Regressive Threshold

      

   Allele Frequency

0.50

0.55

0.52

0.55

0.51

0.51

   Major GeneD

0.96

0.83

0.60

1.52

1.32

1.74

   SexE

0.29

0.29

0.21

0.11

0.10

0.01

   CohortF

0.01

0.01

-0.08

-0.02

0.01

-0.08

   BMIG

   

0.05

0.05

0.05

   SmokingH

   

0.02

0.02

0.05

   DrinkingI

   

0.01

0.01

0.01

   Parent-offspring corr

0.15

0.13

0.16

0.16

0.11

0.12

   Sib-Sib corr

0.00

0.00

0.16

0.08

0.06

0.10

-logL

6558

6679

6600

6477

6604

6537

  1. AUpper value from age interval. BValue at midpoint of interval. CLower value from age interval. DMajor gene effect is measured by the displacement (see Methods). E Sex variable (female vs. male). FCohort variable (offspring vs. original). GBody mass index (weight/height2 in kg/m2). HDaily cigarette consumption. IDaily alcohol consumption (g/day).
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BMC Genomic Data

ISSN: 2730-6844

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