Selecting cases from nuclear families for case-control association analysis

BMC Genomic Data

Table 1 Summary of each selection strategy

Scheme^a	No. families	No. cases	No. controls	Allele freq cases	Allele freq controls	Difference allele freq	Test statistic	Relative efficiency (%)	No. other positive markers
RF	100	100	100	0.350	0.255	0.095	4.28	22	3
AF	100	233	200	0.384	0.232	0.152	18.20	93	7
AF_aff	47	118	100	0.386	0.255	0.131	6.43	33	4
RF_L	50	50	50	0.350	0.260	0.090	1.19	9	5
AF_L	50	110	100	0.373	0.255	0.118	5.35	27	4
SF	100	100	100	0.365	0.255	0.111	5.66	29	4
SF_L	50	50	50	0.360	0.260	0.100	2.33	11	4

^aRF = One affected sib selected randomly from each family, AF = All affected sibs selected from each family, AF_aff = All affected sibs selected from families with affected parents, RF_L = One affected sib selected randomly from families with evidence for linkage, AF_L = All affected sibs from families with evidence for linkage, SF = One affected sib with most evidence of allele-sharing from each family, SF_L = One affected sib with most evidence of allele-sharing from families with evidence for linkage.

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