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Table 4 Association analyses of the GHRH polymorphisms with carcass traits (CW and EMA) among Korean native cattle

From: Growth hormone-releasing hormone (GHRH) polymorphisms associated with carcass traits of meat in Korean cattle

Trait Loci Location Genotype P P COR P WY Q SAM
    C/C* C/R* R/R*     
CW -4241A>T 5'UTR 214(306.2 ± 32.5) 180(315.3 ± 33.1) 34(321.7 ± 36.4) 0.005 0.025 0.025 0.025
  -3195T>A Intron1 140(306.6 ± 35.1) 222(312.6 ± 32.5) 63(314.6 ± 30.8) 0.449 1 0.952 1
  -618T>A Intron1 217(311.9 ± 30.9) 183(310.6 ± 36.3) 27(309.9 ± 34.7) 0.859 1 0.995 0.859
  +114C>A Intron2 199(314.2 ± 34.5) 186(308.8 ± 31.9) 39(309.5 ± 35.7) 0.496 1 0.952 1
  +2042A>G Intron3 276(310.0 ± 35.2) 134(313.6 ± 29.6) 15(317.8 ± 29.1) 0.835 1 0.995 1
  +2279C>T Intron3 206(308.7 ± 32.4) 184(313.3 ± 32.8) 35(316.9 ± 40.9) 0.815 1 0.995 1
  ht1 . 282(313.5 ± 33.1) 129(306.6 ± 34.0) 16(308.9 ± 34.2) 0.219 1 0.474 0.377
  ht2 . 285(311.8 ± 33.9) 128(309.3 ± 32.1) 14(316.3 ± 36.9) 0.594 1 0.509 0.554
  ht4 . 330(312.5 ± 32.5) 90(307.3 ± 37.3) 7(302.4 ± 20.1) 0.174 0.931 0.474 0.59
  ht5 . 332(311.2 ± 34.0) 93(311.6 ± 32.0) 2(299.5 ± 29.0) 0.340 1 0.474 0.401
EMA -4241A>T 5'UTR 214(74.1 ± 8.2) 180(75.7 ± 8.7) 34(78.2 ± 9.3) 0.009 0.046 0.064 0.066
  -3195T>A Intron1 140(75.2 ± 7.6) 222(75.0 ± 8.9) 63(75.6 ± 9.6) 0.583 1 0.991 1
  -618T>A Intron1 217(75.2 ± 8.2) 183(75.2 ± 9.1) 27(74.1 ± 7.7) 0.742 1 0.998 1
  +114C>A Intron2 199(75.1 ± 9.5) 186(75.0 ± 7.8) 39(75.3 ± 6.4) 0.945 1 0.998 0.95
  +2042A>G Intron3 276(75.1 ± 8.5) 134(75.1 ± 8.9) 15(76.8 ± 9.0) 0.799 1 0.998 1
  +2279C>T Intron3 206(74.3 ± 9.3) 184(75.6 ± 7.6) 35(77.5 ± 8.6) 0.920 1 0.998 1
  ht1 . 282(75.2 ± 8.8) 129(75.0 ± 8.3) 16(76.1 ± 5.9) 0.716 1 0.713 0.671
  ht2 . 285(75.6 ± 8.2) 128(74.3 ± 9.1) 14(74.3 ± 9.9) 0.402 1 0.574 0.486
  ht4 . 330(75.7 ± 8.3) 90(73.7 ± 9.3) 7(68.3 ± 6.0) 0.022 0.12 0.088 0.089
  ht5 . 332(75.2 ± 8.9) 93(74.9 ± 7.1) 2(76.0 ± 2.8) 0.316 1 0.528 0.572
  1. Genotype and haplotype distributions, means, standard deviations (SD), P values controlling for sire and age at slaughter as covariates was shown. *C/C, C/R, and R/R represent the common allele, heterozygotes and homozygotes for the rare allele, respectively. To achieve a simple correction for multiple testing of single-nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD) with each other, the effective number of independent marker loci (5.35) in GHRH was calculated using the software SNPSpD [23], on the basis of the spectral decomposition (SpD) of matrices of pair-wise LD between SNPs [24]. PCORrepresents the simple corrected P value. The permutation based P values, PWYwere obtained by the Westfall and Young's method [25]. The FDR values QSAMwere estimated using the permutation test [26].