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Table 1 The effect of host MHC, parasite clone and host gender on the time course of disease symptoms.

From: The separate and combined effects of MHC genotype, parasite clone, and host gender on the course of malaria in mice

  Parasitemia Blood cell counts Body weight change
  F d.f. P F d.f. P F d.f. P
Between subjects
   Host MHC 11.1 1, 38 0.002 3.9 1, 37 0.057 0.1 1, 37 0.79
   Plasmodium clone <0.1 1, 38 0.95 0.9 1, 37 0.35 0.4 1, 37 0.52
   Host gender 0.4 1, 38 0.51 3.1 1, 37 0.09 <0.1 1, 37 1.0
   MHC × clone 0.5 1, 38 0.50 1.5 1, 37 0.24 2.7 1, 37 0.11
   MHC × gender <0.1 1, 38 0.86 0.2 1, 37 0.63 <0.1 1, 37 0.91
   Clone × gender 2.9 1, 38 0.10 8.6 1, 37 0.006 0.3 1, 37 0.62
   MHC × clone × gender 0.1 1, 38 0.79 3.0 1, 37 0.09 4.8 1, 37 0.036
Within subjects (repeated measurements on individual mice)
   Time 79.1 5, 34 <0.0001 88.4 10, 28 <0.0001 15.8 18, 20 <0.0001
   Time × MHC 3.3 5, 34 0.016 0.7 10, 28 0.74 1.0 18, 20 0.53
   Time × clone 4.5 5, 34 0.003 4.3 10, 28 0.001 3.6 18, 20 0.003
   Time × gender 0.2 5, 34 0.95 3.2 10, 28 0.008 2.9 18, 20 0.013
   Time × MHC × clone 0.7 5, 34 0.64 2.2 10, 28 0.051 1.5 18, 20 0.19
   Time × MHC × gender 0.5 5, 34 0.74 1.9 10, 28 0.09 0.6 18, 20 0.86
   Time × clone × gender 1.3 5, 34 0.28 1.4 10, 28 0.22 2.3 18, 20 0.037
   Time × MHC × clone × gender 1.2 5, 34 0.34 1.6 10, 28 0.16 1.5 18, 20 0.18
  1. The experiment was designed for a fully-factorial repeated measures analysis of variance (ANOVA), incorporating the fixed effect factors "host MHC", "host gender", and "Plasmodium clone", with repeated measures of the following dependent variable: parasitemia (6 measurements from day 4–14), blood cell counts (11 measurements from day 1–22), and body weight (19 measurements from day 4–22) given as differences to the weight at day 0. For within-subject analyses we used the multivariate F-tests. One H-2ak male had to be euthanized at day 15 and could therefore only be included in the analysis on parasitemia. P-values that were = 0.05 in analogous tests on other H-2 genotypes [30] are marked in bold.