Table 2 The association between the 14 XRCC1 polymorphisms and bladder cancer risk

EX1-1139

C/C

328 (61.5)

295 (59.0)

1.00

reference

rs2682586

C/T

187 (35.1)

181 (36.2)

1.07 (0.82–1.39)

0.62

Promoter

T/T

18 (3.4)

24 (4.8)

1.42 (0.74–2.71)

0.29

T allele freq.

0.209

0.229

EX1-1128 rs2682585

C/C C/T

319 (60.3) 189 (35.7)

287 (59.1) 177 (36.4)

1.00 1.05 (0.81–1.37)

reference 0.71

Promoter

T/T

21 (4.0)

22 (4.5)

1.15 (0.61–2.18)

0.66

T allele freq.

0.218

0.227

EX1-900

-/-

196 (35.5)

173 (34.0)

1.00

reference

rs3213239

-/+

267 (48.2)

256 (50.3)

1.04 (0.79–1.36)

0.79

Promoter

+/+

91 (16.4)

80 (15.7)

1.02 (0.71–1.48)

0.91

+ allele freq.

0.405

0.409

EX-128

C/C

187 (33.6)

174 (32.8)

1.00

reference

rs3213245

C/T

275 (49.4)

266 (50.2)

1.00 (0.76–1.31)

0.97

5'UTR

T/T

94 (16.9)

90 (17.0)

1.06 (0.74–1.52)

0.76

T allele freq.

0.416

0.421

EX-52

C/C

548 (97.2)

520 (97.6)

1.00

reference

rs2307187

C/T

16 (2.8)

13 (2.4)

0.91 (0.43–1.92)

0.80

5'UTR

T/T

0

0

NC

NC

T allele freq.

0.014

0.012

Val72Ala

C/C

562 (100)

521 (100)

1.00

reference

rs25496

C/T

0

0

NC

NC

Exon 3

T/T

0

0

NC

NC

T allele freq.

0

0

Arg194Trp

C/C

498 (88.6)

476 (89.0)

1.00

reference

rs1799782

C/T

61 (10.9)

56 (10.4)

0.95 (0.64–1.41)

0.81

Exon 6

T/T

3 (0.5)

3 (0.6)

1.01 (0.19–5.23)

0.99

C/T + T/T

64 (11.4)

59 (11.0)

0.95 (0.65–1.40)

0.81

T allele freq.

0.060

0.058

IVS7-33

C/C

518 (91.7)

484 (89.6)

1.00

reference

rs1799780

C/T

47 (8.3)

55 (10.1)

1.30 (0.85–1.97)

0.22

Intron 7

T/T

0 (0)

1 (0.2)

∞

NC

C/T + T/T

47 (8.3)

56 (10.4)

1.33 (0.88–2.01)

0.18

T allele freq.

0.042

0.053

Pro206Pro

G/G

170 (31.2)

162 (31.4)

1.00

reference

rs915927

G/A

270 (49.5)

260 (50.5)

0.96 (0.73–1.28)

0.80

Exon 7

A/A

105 (19.3)

93 (18.1)

0.91 (0.64–1.31)

0.63

A allele freq.

0.440

0.433

Arg280His

G/G

516 (92.1)

456 (88.9)

1.00

reference

rs25489

G/A

41 (7.3)

54 (10.5)

1.52 (0.98–2.34)

0.06

Exon 9

A/A

3 (0.6)

3 (0.6)

1.25 (0.25–6.34)

0.78

G/A + A/A

44 (7.9)

57 (11.1)

1.50 (0.98–2.28)

0.06

A allele freq.

0.042

0.058

Arg399Gln

G/G

226 (40.4)

218 (41.0)

1.00

reference

rs25487

G/A

259 (46.2)

248 (46.6)

0.97 (0.75–1.26)

0.83

Exon 10

A/A

75 (13.4)

66 (12.4)

0.94 (0.64–1.39)

0.76

A allele freq.

0.365

0.357

Gln632Gln

G/G

176 (31.4)

173 (32.2)

1.00

reference

rs3547

G/A

275 (49.0)

268 (49.9)

0.94 (0.72–1.24)

0.67

Exon 17

A/A

110 (19.6)

96 (17.8)

0.87 (0.61–1.23)

0.43

A allele freq.

0.441

0.428

EX17-123

-/-

492 (89.5)

448 (88.4)

1.00

reference

rs3213401

-/+

55 (10.0)

56 (11.0)

1.18 (0.79–1.76)

0.43

3'UTR

+/+

3 (0.5)

3 (0.6)

0.78 (0.15–4.09)

0.77

-/+ plus +/+

58 (10.5)

59 (11.6)

1.15 (0.78–1.70)

0.48

+ allele freq.

0.055

0.061

EX17-127

G/G

337 (64.1)

320 (65.6)

1.00

rs2682558

G/A

162 (30.8)

142 (29.1)

0.91 (0.69–1.20)

0.48

3'UTR

A/A

27 (5.1)

26 (5.3)

1.13 (0.64–1.99)

0.68

A allele freq.

0.205

0.199