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Table 1 Association analysis in the extended T1D family set.

From: Sequencing and association analysis of the type 1 diabetes – linked region on chromosome 10p12-q11

Gene Polymorphism Allele 1/2c Affected offspring Allele 1, Transmitted (%) Allele 1, Non-transmitted (%) P-value TDT Allele 1, frequency d
PAPD1       
Rs639299a G/A 2029 777 (48.2) 834 (51.8) 0.16 0.69
rs1963187a A/T 2383 272 (56.1) 213 (43.9) 0.0074 0.95
rs2480285a G/A 2642 785 (46.3) 909 (53.7) 0.0026 0.21
D10S1426a   1401    0.21  
  *158   502 (52.7) 450 (47.3) 0.092 0.27
  *162   502 (48.4) 535 (51.6) 0.31 0.33
  *166   420 (52.3) 383 (47.7) 0.19 0.23
D10S193a   1932    0.037  
  *220   587 (46.6) 673 (53.4) 0.015 0.28
  *224   781 (52.2) 716 (47.8) 0.093 0.35
  *226   363 (55.1) 296 (44.9) 0.0091 0.11
  *228   185 (47.8) 202 (52.2) 0.39 0.07
rs540994 b A/C 2096 941 (51.4) 889 (48.6) 0.22 0.45
ss48399034b A/T 2124 178 (58.4) 127 (41.6) 0.0035 0.96
rs1047991b G/A 2382 849 (48.1) 916 (51.9) 0.11 0.73
rs11818836b A/G 2087 958 (52.2) 876 (47.8) 0.056 0.45
ss48399025b A/C 2284 388 (54.0) 330 (46.0) 0.030 0.90
ss48399036b A/G 3207 137 (55.0) 112 (45.0) 0.11 0.02
ss48399044b T/A 2061 461 (46.6) 529 (53.4) 0.031 0.83
NRP1       
rs13324a A/G 2134 826 (50.6) 806 (49.4) 0.62 0.30
rs1048804a A/G 2047 661 (47.7) 725 (52.3) 0.086 0.75
rs1010826a A/G 2125 737 (51.9) 683 (48.1) 0.15 0.24
MYO3A       
rs1339816 a A/G 2107 820 (47.7) 898 (52.3) 0.060 0.35
rs2096176 a A/G 2116 893 (47.6) 984 (52.4) 0.036 0.42
HNRPF       
rs1416226a A/G 2090 728 (53.5) 632 (46.5) 0.0092 0.23
SVIL       
rs2274494a A/G 2152 894 (47.5) 987 (52.5) 0.032 0.37
rs11600a A/G 2147 432 (47.5) 477 (52.5) 0.14 0.13
Intergenic       
rs787025 a A/C 2038 237 (45.6) 283 (54.4) 0.044 0.06
BMS1L       
rs787795a A/G 2102 537 (53.4) 469 (46.6) 0.032 0.86
  1. a – polymorphism genotyped in the initial scan, b – polymorphisms genotyped after being identified by resequencing of the PAPD1-MAP3K8 gene region, c – alleles encoded as 1and 2 for SNPs or as size of an allele for STRs, d – allele frequency among parents of T1D patients from the UK is shown; TDT – transmission disequilibrium test