Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes

Table 3 SNP haplotypes in COMT gene

^aHaplotype	DM (393) n;f*	CRI (372) n;f*	χ²	P	OR (95% CI)
1111	50 (0.127)	64 (0.172)	3.18	0.074	1.44 (0.96–2.15)
1112	33 (0.084)	04 (0.01)	20.48	^b < 0.001	0.12 (0.04–0.34)
1121	59 (0.150)	50 (0.134)	0.33	0.56	0.89 (0.59–1.33)
1122	03 (0.007)	28 (0.075)	22.69	^b < 0.001	10.66 (3.21–35.38)
1211	39 (0.01)	43 (0.115)	0.08	0.78	1.07 (0.67–1.68)
1212	55 (0.14)	51 (0.137)	0.005	0.94	0.98 (0.65–1.48)
1221	06 (0.015)	02 (0.005)
2111	23 (0.058)	24 (0.064)	0.138	0.71	1.12 (0.62–2.02)
2112	00 (0.00)	04 (0.01)
2121	103 (0.262)	62 (0.166)	9.927	^b 0.0016	0.57 (0.40–0.81)
2122	13 (0.033)	20 (0.05)	2.04	0.15	1.67 (0.82–3.41)
2211	01 (0.002)	08 (0.021)
2212	06 (0.015)	05 (0.013)	0.04	0.84	0.89 (0.27–2.92)
2221	02 (0.005)	07 (0.019)

^aOrder of SNPs in the COMT haplotypes: -287 A>G, 408 C>G, 472 G > A and 900 Ins/Del C
^bSignificant after Bonferroni's correction α = 0.0035
*n = total number
**f = frequency

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