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Table 3 SNP haplotypes in COMT gene

From: Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes

aHaplotype DM (393) n*;f** CRI (372) n*;f** χ2 P OR (95% CI)
1111 50 (0.127) 64 (0.172) 3.18 0.074 1.44 (0.96–2.15)
1112 33 (0.084) 04 (0.01) 20.48 b < 0.001 0.12 (0.04–0.34)
1121 59 (0.150) 50 (0.134) 0.33 0.56 0.89 (0.59–1.33)
1122 03 (0.007) 28 (0.075) 22.69 b < 0.001 10.66 (3.21–35.38)
1211 39 (0.01) 43 (0.115) 0.08 0.78 1.07 (0.67–1.68)
1212 55 (0.14) 51 (0.137) 0.005 0.94 0.98 (0.65–1.48)
1221 06 (0.015) 02 (0.005)    
2111 23 (0.058) 24 (0.064) 0.138 0.71 1.12 (0.62–2.02)
2112 00 (0.00) 04 (0.01)    
2121 103 (0.262) 62 (0.166) 9.927 b 0.0016 0.57 (0.40–0.81)
2122 13 (0.033) 20 (0.05) 2.04 0.15 1.67 (0.82–3.41)
2211 01 (0.002) 08 (0.021)    
2212 06 (0.015) 05 (0.013) 0.04 0.84 0.89 (0.27–2.92)
2221 02 (0.005) 07 (0.019)    
  1. aOrder of SNPs in the COMT haplotypes: -287 A>G, 408 C>G, 472 G > A and 900 Ins/Del C
  2. bSignificant after Bonferroni's correction α = 0.0035
  3. *n = total number
  4. **f = frequency