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Table 3 Number of parameters in latent class model, by number of laboratories (R)

From: Use of latent class models to accommodate inter-laboratory variation in assessing genetic polymorphisms associated with disease risk

Model number Association of interest Accuracy differential by laboratory General number of labs (R) R = 1 R = 2 R = 3
1 Observed vs. true exposure status: EX Yes 2R + 2 4 6 8
2   Yes* 4R + 2 6 10 14
3   No 4 4 4 4
4   No* 6 6 6 6
5 Disease vs. true exposure status: DX Yes 2R + 3 5 7 9
6   No 5 5 5 5
7 Disease with observed exposure status: DE Yes 2R + 1 3 5 7
8   No 3 3 3 3
  1. * error rates are (additionally) differential by disease status
  2. D- disease; X-true genotype status; E-genotype status measured by laboratory test.