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Table 3 Mean ± SEM for anthropometric measures, body composition, and serum lipid profile of study subjects stratified according to LAMA5 rs659822 or rs944895 genotype and ethnicity.

From: Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans

 

European American

African American

rs659822

C/C

C/T

T/T

P*

C/C

C/T

T/T

P

   n

13

42

46

 

29

69

29

 

   BMI

26.8 ± 0.5

27.6 ± 0.3

27.7 ± 0.3

0.1

28.2 ± 0.4

27.2 ± 0.3

27.4 ± 0.4

0.3

   Height (cm)

162.6 ± 1.2

164.6 ± 0.8

167.3 ± 1.1

0.02

164.9 ± 1.2

164.1 ± 0.8

162.5 ± 1.4

0.2

   Weight (kg)

69.8 ± 2.3

74.7 ± 1.3

78.2 ± 1.4

0.008

76.5 ± 1.7

73.2 ± 1.1

71.9 ± 1.5

0.05

   Total fat mass (kg)

28.8 ± 1.9

31.5 ± 1.0

33.7 ± 1.0

0.01

31.3 ± 1.2

30.3 ± 0.9

29.4 ± 1.1

0.3

   Lean tissue mass (kg)

37.6 ± 0.8

39.9 ± 0.5

41.2 ± 0.5

0.003

41.4 ± 0.8

39.5 ± 0.5

38.7 ± 0.8

0.03

   Triacylglycerol (mg/dl)

104.9 ± 11.5

120.5 ± 11.4

112.9 ± 6.3

0.8

68.1 ± 4.7

65.8 ± 3.2

70.3 ± 4.3

0.6

   Total cholesterol (mg/dl)

153.4 ± 6.3

163.0 ± 4.9

159.6 ± 4.9

0.8

162.3 ± 6.5

150.1 ± 3.8

163.1 ± 6.9

0.6

   HDL-cholesterol (mg/dl)

42.4 ± 2.4

36.0 ± 1.6

34.5 ± 1.1

0.003 a

46.1 ± 1.8

41.2 ± 1.3

45.2 ± 2.1

0.07a

   LDL-cholesterol (mg/dl)

90.0 ± 5.8

102.9 ± 4.1

102.5 ± 4.1

0.5

102.7 ± 6.2

95.8 ± 3.6

103.8 ± 6.4

0.9

rs944895

        

   n

9

50

42

 

28

66

33

 

   BMI

26.6 ± 0.7

27.5 ± 0.3

27.8 ± 0.3

0.3

27.8 ± 0.4

27.6 ± 0.3

27.1 ± 0.4

0.5

   Height (cm)

163.1 ± 1.2

165.6 ± 1.0

166.0 ± 0.9

0.3

163.9 ± 1.4

164.4 ± 0.8

163.1 ± 1.2

0.6

   Weight (kg)

70.9 ± 2.8

75.5 ± 1.3

76.9 ± 1.3

0.09

73.5 ± 1.4

74.5 ± 1.2

72.1 ± 1.6

0.7

   Total fat mass (kg)

28.2 ± 2.1

31.7 ± 1.0

33.3 ± 1.0

0.1

29.9 ± 1.1

30.7 ± 0.9

29.7 ± 1.2

0.5

   Lean tissue mass (kg)

38.5 ± 1.1

40.5 ± 0.6

40.2 ± 0.5

0.7

40.0 ± 0.8

40.2 ± 0.5

38.8 ± 0.9

0.4

   Triacylglycerol (mg/dl)

101.8 ± 8.6

117.3 ± 9.2

115.2 ± 8.1

0.9

78.9 ± 5.1

65.7 ± 3.1

60.9 ± 4.0

0.02

   Total cholesterol (mg/dl)

159.8 ± 7.5

161.2 ± 4.6

159.2 ± 4.9

0.7

156.5 ± 5.6

159.4 ± 4.2

148.3 ± 6.5

0.7

   HDL-cholesterol (mg/dl)

41.2 ± 3.1

35.1 ± 1.4

36.3 ± 1.3

0.5b

43.4 ± 2.1

45.2 ± 1.4

39.1 ± 1.5

0.03 b

   LDL-cholesterol (mg/dl)

98.2 ± 8.6

102.7 ± 3.8

99.8 ± 4.1

0.7

97.4 ± 5.1

101.1 ± 4.0

97.0 ± 6.1

1

  1. * P values represent the significance of the comparison among genotypes. P values without subscript were calculated assuming additive models. P values with subscripts (a) and (b) were calculated assuming recessive and dominant models, respectively. P values significant after permutations tests to correct for multiple comparisons are highlighted in bold case
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