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Table 3 Mean ± SEM for anthropometric measures, body composition, and serum lipid profile of study subjects stratified according to LAMA5 rs659822 or rs944895 genotype and ethnicity.

From: Genetic variation in a member of the laminin gene family affects variation in body composition in Drosophila and humans

  European American African American
rs659822 C/C C/T T/T P* C/C C/T T/T P
   n 13 42 46   29 69 29  
   BMI 26.8 ± 0.5 27.6 ± 0.3 27.7 ± 0.3 0.1 28.2 ± 0.4 27.2 ± 0.3 27.4 ± 0.4 0.3
   Height (cm) 162.6 ± 1.2 164.6 ± 0.8 167.3 ± 1.1 0.02 164.9 ± 1.2 164.1 ± 0.8 162.5 ± 1.4 0.2
   Weight (kg) 69.8 ± 2.3 74.7 ± 1.3 78.2 ± 1.4 0.008 76.5 ± 1.7 73.2 ± 1.1 71.9 ± 1.5 0.05
   Total fat mass (kg) 28.8 ± 1.9 31.5 ± 1.0 33.7 ± 1.0 0.01 31.3 ± 1.2 30.3 ± 0.9 29.4 ± 1.1 0.3
   Lean tissue mass (kg) 37.6 ± 0.8 39.9 ± 0.5 41.2 ± 0.5 0.003 41.4 ± 0.8 39.5 ± 0.5 38.7 ± 0.8 0.03
   Triacylglycerol (mg/dl) 104.9 ± 11.5 120.5 ± 11.4 112.9 ± 6.3 0.8 68.1 ± 4.7 65.8 ± 3.2 70.3 ± 4.3 0.6
   Total cholesterol (mg/dl) 153.4 ± 6.3 163.0 ± 4.9 159.6 ± 4.9 0.8 162.3 ± 6.5 150.1 ± 3.8 163.1 ± 6.9 0.6
   HDL-cholesterol (mg/dl) 42.4 ± 2.4 36.0 ± 1.6 34.5 ± 1.1 0.003 a 46.1 ± 1.8 41.2 ± 1.3 45.2 ± 2.1 0.07a
   LDL-cholesterol (mg/dl) 90.0 ± 5.8 102.9 ± 4.1 102.5 ± 4.1 0.5 102.7 ± 6.2 95.8 ± 3.6 103.8 ± 6.4 0.9
rs944895         
   n 9 50 42   28 66 33  
   BMI 26.6 ± 0.7 27.5 ± 0.3 27.8 ± 0.3 0.3 27.8 ± 0.4 27.6 ± 0.3 27.1 ± 0.4 0.5
   Height (cm) 163.1 ± 1.2 165.6 ± 1.0 166.0 ± 0.9 0.3 163.9 ± 1.4 164.4 ± 0.8 163.1 ± 1.2 0.6
   Weight (kg) 70.9 ± 2.8 75.5 ± 1.3 76.9 ± 1.3 0.09 73.5 ± 1.4 74.5 ± 1.2 72.1 ± 1.6 0.7
   Total fat mass (kg) 28.2 ± 2.1 31.7 ± 1.0 33.3 ± 1.0 0.1 29.9 ± 1.1 30.7 ± 0.9 29.7 ± 1.2 0.5
   Lean tissue mass (kg) 38.5 ± 1.1 40.5 ± 0.6 40.2 ± 0.5 0.7 40.0 ± 0.8 40.2 ± 0.5 38.8 ± 0.9 0.4
   Triacylglycerol (mg/dl) 101.8 ± 8.6 117.3 ± 9.2 115.2 ± 8.1 0.9 78.9 ± 5.1 65.7 ± 3.1 60.9 ± 4.0 0.02
   Total cholesterol (mg/dl) 159.8 ± 7.5 161.2 ± 4.6 159.2 ± 4.9 0.7 156.5 ± 5.6 159.4 ± 4.2 148.3 ± 6.5 0.7
   HDL-cholesterol (mg/dl) 41.2 ± 3.1 35.1 ± 1.4 36.3 ± 1.3 0.5b 43.4 ± 2.1 45.2 ± 1.4 39.1 ± 1.5 0.03 b
   LDL-cholesterol (mg/dl) 98.2 ± 8.6 102.7 ± 3.8 99.8 ± 4.1 0.7 97.4 ± 5.1 101.1 ± 4.0 97.0 ± 6.1 1
  1. * P values represent the significance of the comparison among genotypes. P values without subscript were calculated assuming additive models. P values with subscripts (a) and (b) were calculated assuming recessive and dominant models, respectively. P values significant after permutations tests to correct for multiple comparisons are highlighted in bold case