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Table 3 Power results1

From: In search of causal variants: refining disease association signals using cross-population contrasts

Minor allele frequency in
2nd population
Significance level (α) required Power (%) to detect significant
population*genotype interaction2
0.3 0.1 73.9
  0.05 60.8
0.2 0.1 67.9
  0.05 51.7
0.1 0.1 49.6
  0.05 34.2
0.05 0.1 34.1
  0.05 24.6
  1. 1From simulation, assuming rs16969968 has no effect and a range of allele frequencies in the second population sample of 344 cases and 239 controls.
  2. 2When the population*genotype interaction term is significant, we filter the SNP from priority consideration.