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Table 4 Summary of results in Table 3

From: Application of two machine learning algorithms to genetic association studies in the presence of covariates

MODEL Include Z Residualize by Z Ignore Z
MODEL 1: ADDITIVE +/- +/+ +/+
MODEL 2: ADDITIVE WITH CONFOUNDING +/- +/- - -/-
MODEL 3: ADDITIVE WITH EFFECT MEDIATION +/- - -/- - -/-
MODEL 4: INTERACTION WITH MAIN EFFECT +/+ +/+ +/+
MODEL 5: INTERACTION WITH NO MAIN EFFECT +/+ - -/- - - -/- -
MODEL 6: CONDITIONAL ASSOCIATION +/+ - -/- - - -/- -
  1. Results are given in pairs corresponding to RF and MARS, respectively:
  2. "+" denotes reasonable TDR (> 80%) to detect genotype;
  3. "-" denotes lower TDR (50% – 80%) to detect genotype;
  4. and "--" denotes very low TDR (< 50%) to detect genotype.