Association of TNF-alpha, IL-6 and IL-1beta gene polymorphisms with polycystic ovary syndrome: a meta-analysis

BMC Genomic Data

Table 4 Meta-analysis of IL-1beta (−511 C/T) polymorphism and PCOS risk

Comparison	No. of studies	T vs. C		TT vs. CC		TC vs. CC		TT + CT vs. CC		TT vs. CT + CC
Comparison	No. of studies	OR (95% CI)	P _H	OR (95% CI)	P _H	OR (95% CI)	P _H	OR (95% CI)	P _H	OR (95% CI)	P _H
Overall	4	1.11 (0.67-1.84)^R	<0.01	0.89 (0.62-1.27)^R	<0.01	0.91 (0.40-2.11)^R	<0.01	1.00 (0.45-2.19)^R	<0.01	1.26 (0.62-2.53)^R	<0.01
HWE in controls	3	1.08 (0.54-2.14)^R	<0.01	1.16 (0.29-4.61)^R	<0.01	0.65 (0.33-1.28)^R	0.041	0.79 (0.34-1.86)^R	<0.01	1.50 (0.53-4.25)^R	<0.01
Asian/PCR-RFLP	3	1.17 (0.57-2.42)^R	<0.01	1.29 (0.33-5.09)^R	<0.01	0.92 (0.27-3.18)^R	<0.01	1.03 (0.32-3.30)^R	<0.01	1.37 (0.53-3.54)^R	<0.01
Sample size > 200	3	0.90 (0.58-1.37)^R	0.014	0.70 (0.47-1.03)^R	0.014	0.91 (0.31-2.67)^R	<0.01	0.86 (0.33-2.21)^R	<0.01	0.83 (0.60-1.14)^F	0.769

OR, odds ratio; CI, confidence interval; No., number; vs.: versus; P _H, p value of Q-test for heterogeneity test; ^Rrandom-effect model; ^Ffixed-effect model.

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