Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans

BMC Genomic Data

Table 3 The effects of amino acids on lifespan in aak-2, sir-2.1 and eat-2 mutant and bec-1 knockdown worms

Strain	Treatment	% of N2 control mean lifespan	% of untreated mean lifespan	p-value	# of worms	Replicates
aak-2(gt33)	Control	80		<0.001	786	8
	5 mM histidine		100	0.877	189	2
	5 mM proline		100	0.919	187	2
	1 mM alanine		100	0.943	209	2
	1 mM tryptophan		102	0.060	220	2
	10 mM serine		101	0.137	204	2
	5 mM lysine		87	0.373	180	2
	5 mM cysteine		85	0.952	140	2
	10 mM cysteine		90	0.122	145	2
	5 mM tyrosine		80	<0.001	200	2
	5 mM glutamine		94	0.436	180	2
	10 mM glutamine		103	0.126	200	2
sir-2.1(ok434)	Control	86		<0.001	299	4
	5 mM histidine		100	<0.830	154	2
	5 mM proline		104	0.211	114	2
	1 mM alanine		98	0.225	165	2
	1 mM tryptophan		102	0.673	121	2
	10 mM serine		101	0.482	136	2
	10 mM glutamine		110	<0.001	180	2
	5 mM cysteine		105	0.244	192	2
	10 mM cysteine		110	<0.001	190	2
	5 mM tyrosine		93	0.231	131	2
	5 mM lysine		107	0.017	146	2
	1 mM phenylalanine		105	0.049	155	2
	10 mM phenylalanine		101	0.402	176	2
eat-2(ad1116)	Control	142		<0.001	135	2
	10 mM serine		108	0.078	161	2
	1 mM tryptophan		105	0.099	138	2
	5 mM glutamine		100	0.841	134	2
	5 mM histidine		106	0.091	153	2
	5 mM proline		107	0.076	176	2
N2 (bec-1 RNAi) with live bacteria	Control	123		<0.001	184	2
	1 mM tryptophan		107	<0.001	162	2
	10 mM serine		101	0.316	152	2
	5 mM histidine		99	0.274	117	2
	5 mM proline		98	0.09	102	2

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