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Table 3 Association analysis of AKR1B10 variants in the replication cohort

From: Genetic variants in AKR1B10 associate with human eating behavior

AKR1B10 genotype

 

rs10232478

rs782881

rs1834150

Genotype ( N )

CC (50)

CT (131)

TT (99)

CC (65)

AC (146)

AA (81)

TT (56)

TA (136)

AA (82)

age

27.14 ± 5.46

26.40 ± 4.87

26.53 ± 4.71

26.80 ± 5.54

26.64 ± 4.97

26.91 ± 4.84

26.70 ± 4.82

26.43 ± 5.03

27.50 ± 5.01

p-value

n.s.

n.s.

n.s.

BMI

27.6 ± 6.53

26.92 ± 6.16

27.21 ± 6.49

27.64 ± 6.67

26.90 ± 5.93

27.36 ± 6.59

26.98 ± 5.94

27.34 ± 6.20

27.11 ± 6.59

p-value

n.s.

n.s.

n.s.

association analysis with eating behavior factors

Disinhibition

6.64 ± 3.34

6.05 ± 3.12

6.33 ± 3.02

6.15 ± 3.11

6.33 ± 3.22

6.01 ± 3.29

6.29 ± 3.06

6.56 ± 3.31

6.01 ± 3.21

p-value

n.s.

n.s.

n.s.

Hunger

4.63 ± 2.87

5.57 ± 3.48

5.88 ± 3.26

4.80 ± 3.3

5.72 ± 3.51

5.76 ± 3.42

4.72 ± 3.18

5.99 ± 3.57

5.54 ± 3.37

p-value

°0.038 "0.036

n.s.

n.s.

Restraint

7.85 ± 5.23

6.30 ± 4.41

5.55 ± 4.23

7.27 ± 4.91

6.16 ± 4.22

5.42 ± 4.29

7.35 ± 5.14

5.99 ± 4.13

5.25 ± 4.06

p-value

°0.010 "0.015

°0.027

°0.007 #0.049 "0.015

  1. Data are presented as mean ± SD. Type 2 diabetics were excluded. P-values were calculated using additive, dominant (mm + mM vs. MM) and recessive (mm vs mM + MM) model of inheritance using linear regression adjusted for age, sex and lnBMI (except for BMI); ° = additive model of inheritance; # = dominant model of inheritance; “=recessive model of inheritance; n.s. non-significant; significant P-values are highlighted in bold; N = number of individuals; BMI = Body Mass Index.