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Table 4 Generalized linear and logistic regression models showing the effects of genes on kidney functions and other continuous predictors (recessive model)

From: APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans

   Overall
Allele Phenotype Effects size (95 % CI) P
rs60910145 G/G Serum creatinine (loge[μmol/l]) 0.192 (-0.094 to 0.478) 0.289
  eGFR (MDRD) [ml/min] −18.54 (-48.59 to 11.51) 0.227
  eGFR (CKD-EPI) [ml/min] −18.90 (-43.76 to 5.96) 0.136
  Prevalent CKD (MDRD) 23.47 (0.92 to 599.29) 0.074
  Prevalent CKD (CKD-EPI) 42.72 (1.22 to ∞) 0.047
  Albumin/creatinine ratio (loge[mg/mmol]) −1.02 (-2.62 to 0.57) 0.210
  Systolic blood pressure (mmHg) −0.36 (-27.67 to 26.74) 0.979
rs73885319 G/G Serum creatinine (loge[μmol/l]) 0.191 (-0.094 to 0.478) 0.189
  eGFR (MDRD) [ml/min] −18.54 (-48.59 to 11.51) 0.227
  eGFR (CKD-EPI) [ml/min] −18.90 (-43.76 to 5.96) 0.136
  Prevalent CKD (MDRD) 23.47 (0.92 to 599.29) 0.074
  Prevalent CKD (CKD-EPI) 42.72 (1.22 to ∞) 0.047
  Albumin/creatinine ratio (loge[mg/mmol]) −1.02 (-2.62 to 0.57) 0.210
  Systolic blood pressure (mmHg) −0.36 (-27.67 to 26.94) 0.979
rs71785313 Del/Del Serum creatinine (loge[μmol/l]) 0.038 (-0.144 to 0.219) 0.684
  eGFR (MDRD) [ml/min] −7.16 (-26.19 to 11.87) 0.461
  eGFR (CKD-EPI) [ml/min] −5.99 (-21.74 to 9.76) 0.456
  Prevalent CKD (MDRD) 0.0 -
  Prevalent CKD (CKD-EPI) 0.0 -
  Albumin/creatinine ratio (loge[mg/mmol]) −0.123 (-1.134 to 0.888) 0.811
  Systolic blood pressure (mmHg) −6.27 (-23.55 to 11.02) 0.478
  1. Models are adjusted for age, sex, diabetes status and hypertension
  2. Effect estimates are mean difference and 95 % confidence intervals for quantitative traits and odds ratio and 95 % confidence intervals for qualitative traits
  3. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease