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Table 1 Sub-studies included from the GABRIEL Consortium

From: Genome-wide search identifies a gene-gene interaction between 20p13 and 2q14 in asthma

Study component Sub-study Reference Country of origin Case definition Control definition N, cases N, controls
Screening GABRIEL-AS [28] Austria, Germany, Switzerland Ever had doctor-diagnosed asthma or had asthmatic bronchitis at least twice (self-report). Did not ever have doctor-diagnosed asthma and no asthmatic bronchitis diagnosed at least twice (self-report). 802 823
Follow-up BAMSE [30] Sweden Ever had doctor-diagnosed asthma (self-report). Did not have a history of asthma or other allergic diseases (self-report). 226 235
BUSSELTON [31] Australia Ever had doctor-diagnosed asthma (self-report). Did not ever have doctor-diagnosed asthma (self-report). 520 685
EGEA [32] France Ever had asthma attacks (self-report). Did not ever have asthma attacks (self-report). 120 444
KMSU [33] Russia Asthma diagnosed on the basis of symptoms (recurrent cough, wheezing, or dyspnea), airway obstruction reversibility, or airway methacholine hyper-responsiveness. No symptoms or history of allergic disease, normal total serum IgE, normal pulmonary function. 285 261
PIAMA [34] The Netherlands Ever had doctor-diagnosed asthma (self-report). Did not have a history of asthma or other allergic diseases (self-report). 174 187
SAPALDIA [35] Switzerland Ever had asthma (self-report). Did not ever have asthma (self-report). 581 880
UFA N/A Russia Asthma diagnosed on the basis of clinical examination, family and medication history, and lung function tests. No symptoms or history of asthma or other pulmonary disease, no symptoms or history of atopy, no first-degree relatives with a history of asthma or atopy. 333 333
  Sub-total (Follow-up) 2239 3025
Replication AUGOSA [36] United Kingdom Severe asthma (determined based on clinical assessments and control of symptoms) N/A 625 0
KARELIA [37] Finland, Russia Ever had doctor-diagnosed asthma (self-report). Did not ever have doctor-diagnosed asthma (self-report). 57 68
MAS [38] Germany Ever had doctor-diagnosed asthma. N/A 173 0
SEVERE [39] United Kingdom Severe asthma (determined based on clinical assessments and control of symptoms) N/A 290 0
  Sub-total (Replication) 1145 68
  Total (all) 4186 3916
  1. More complete case/control definitions may be available in the indicated references or the supplement to Moffatt et al. [12]. Subject counts reflect final numbers for inclusion, after quality control procedures were applied