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Table 5 Suggestive and significant evidence for QTLs influencing anxiety-related behavior and/or locomotion in the mHB of male inbred micea

From: Consomic mouse strain selection based on effect size measurement, statistical significance testing and integrated behavioral z-scoring: focus on anxiety-related behavior and locomotion

MOTIVATIONAL SYSTEM / Behavioral dimension / Behavioral variables

Chromosomes

Type of analysisb

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

18

19

X

Y

QTLs influencing the difference in mHB behavior between male C57BL/6J and A/J mice

Locomotion

X c

x

x

X

x

X

X

x

Z

Total number of line crossings

X

X

X

x

X

X

X

X

X

X

X

X

x

U

Latency until the first line crossing

x

X

x

x

x

x

X

U

Factor 1 – DI/ME/LOd

X

x

X

x

X

x

x

x

X

U

ANXIETY corrected for Locomotion

x

Z

ANXIETY

x

x

x

x

x

Z

Avoidance

x

x

x

Z

Total number of board entries

X

U

Latency until the first board entry

x

X

x

U

Percentage of time on the board

U

Average duration of a board entry

x

X

U

Latency until the first board entry + Percentage of time on the board

x

X

B

Latency until the first board entry + Average duration of a board entry

x

X

x

x

X

B

Factor 2 – AV/UN/OT

x

F

Risk assessment

x

x

x

Z

Total number of stretched attends

x

X

X

x

X

x

U

Latency until the first stretched attend

x

X

x

U

Factor 7 – RI/UN

X

x

X

x

X

x

x

X

F

Arousal

x

Z

Total number of self-groomings

U

Latency until the first self-grooming

x

U

Percentage of time self-grooming

U

Average duration of a self-grooming

U

Latency until the first self-grooming + Percentage of time self-grooming

B

Latency until the first self-grooming + Average duration of a self-grooming

B

Total number of defecations

x

U

Latency until the first bolus

U

Total number of urinations

x

U

Latency until the first urination

x

U

Factor 3 – AR

X

U

Factor 4 – OT

x

x

x

X

F

Factor 6 – AR

F

  1. a Based on n = 27 host and n = 6 consomic mice
  2. b Finding evidence for a QTL on a particular chromosome was based on different methods: Z = effect size measurement, statistical significance testing (ANCOVA plus bootstrapped P values) and integrated behavioral z-scoring [this study]; U = univariate statistical analysis [8] (unpaired Student’s t test, unpaired Student’s t test with Welch-Satterthwaite correction, Wilcoxon-Mann–Whitney test); B = bivariate statistical analysis [8] (Hotelling’s T 2 test); F = Factor analysis [8]
  3. c X = significant, x = suggestive, and – = no evidence for a QTL on a particular chromosome
  4. d The factors are labelled with the behavioral dimensions they mainly reflect. Abbreviations used: AR arousal, AV avoidance, DI directed exploration, LO locomotion, ME memory, OT other behavior, RI risk assessment, UN undirected exploration