Fig. 5

Conservation and rewiring of genetic control of locomotor behaviors between worms and flies. a The examined set was enriched with genes expressed in the neurons. b The examined genes were enriched with locomotor phenotypes. In (a) and (b), expected background values were computed using Flybase annotations for all genes (All) or genes with C. elegans orthologs (Ce ortholog). *, p < 0.01 comparing observed value (FlyBase alone, or combined data from FlyBase and this study) with both expected values, Fisher’s exact test. c, d Mild conservation of genetic interactions, if interaction was defined using both |PCC| for locomotive profiles and high GeneOrienteer scores (c) or only |PCC| values (d). Both neuronal and ubiquitous profiles were analyzed. Observed values were computed using fly gene pairs with interacting worm orthologous pairs. Expected values were computed using all combinations of genes. * indicates p < 0.01 comparing observed and expected values, Fisher’s exact test