
pvalue PM_{2.5}

pvalue PM_{2.5} absorbance

pvalue PM_{10}

pvalue NO_{2}


Best SNP^{1} (raw pvalue^{2})

0.016

0.040

0.064

0.012

Best SNP^{1} (Bonferronicorrected pvalue)

0.130

0.316

0.516

0.095

Weighted GRS^{3} (pvalue GRSxE term)

0.014

0.063

0.102

0.078

Unweighted GRS (pvalue GRSxE term)

0.038

0.062

0.249

0.122

 Interaction between air pollution exposure and eight SNPs of the endoplasmatic reticulum (ER) stress pathway on the levels of leukotriene (LT) B_{4} measured in induced sputum (low vs. high, cut point at 3rd quartile) in 402 women from the SALIA study (pvalues are given for the GxE interaction). Air pollution exposures: PM_{2.5}: fine inhalable particles, with diameters that are generally 2.5 μm and smaller; PM_{2.5} absorbance: filter absorbance of PM_{2.5} (soot); PM_{10}: inhalable particles, with diameters that are generally 10 μm and smaller; NO_{2}: Nitrogen dioxide
 All models were adjusted for age, BMI (kg/m^{2}), smoking history, passive smoking, level of education and indoor air pollution (heating with fossil fuels and exposure to indoor mold)

^{1}: The “best SNP” (additive model) had the lowest pvalue for the marginal genetic effect as well as for the GxE interaction term (rs2254958, compare Hüls et al. [12])

^{2}: Pvalues derived from individual SNP by exposure interaction estimates, not corrected for the number of SNPs tested

^{3}: weights were estimated by applying a lasso regression on the combined marginal genetic effects of all eight SNPs on the binary health outcome (low vs. high levels of leukotriene (LT) B_{4})