Skip to main content

Table 3 Summary of SNPs with meta-analysis p-values ≤8.0 × 10−7

From: Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes

SNP CHR Position Nearest Gene Alleles Outcome MOI AA-DHSa JHSb Meta-Analysis
Estimate SE P-value Estimate SE P-value DE P-value
rs113533135 2 141,026,436 LRP1B T/C CAC > =10 vs. CAC < 10 Dominant 0.19 0.05 1.7 × 10−4 0.30 0.08 3.1 × 10−4 3.3 × 10−7
rs6754498 2 186,817,848   A/G Log(CAC + 1) Dominant 0.83 0.22 1.9 × 10−4 1.12 0.32 5.2 × 10−4 ++ 5.5 × 10−7
rs9973676 2 231,818,806 GPR55 A/G CAC > =10 vs. CAC < 10 Dominant −0.20 0.05 5.8 × 10−5 −0.22 0.07 3.1 × 10−3 6.4 × 10−7
rs6898559 5 125,892,929 ALDH7A1 A/G CAC > =10 vs. CAC < 10 Additive 0.09 0.03 4.1 × 10−4 0.18 0.04 4.3 × 10−5 5.0 × 10−7
rs16879003 6 16,745,239 ATXN1 T/C CAC > =10 vs. CAC < 10 Additive −0.19 0.04 7.0 × 10−6 −0.20 0.07 4.7 × 10−3 ++ 1.1 × 10−7
rs113805659 7 78,292,791 MAGI2 C/G CAC > =10 vs. CAC < 10 Additive −0.19 0.04 5.5 × 10−6 −0.21 0.08 7.5 × 10−3 1.4 × 10−7
rs117854110 7 105,243,449   T/C Log(CAC + 1) Dominant −2.74 0.66 4.2 × 10−5 −2.72 0.91 2.9 × 10−3 4.5 × 10−7
rs58071836 7 118,273,539   T/C CAC > =10 vs. CAC < 10 Additive −0.13 0.04 1.7 × 10−4 −0.21 0.06 2.2 × 10−4 ++ 2.8 × 10−7
rs10978777* 9 110,030,590   C/G Log(CAC + 1) Additive −0.63 0.16 1.3 × 10−4 −0.95 0.24 8.7 × 10−5 1.2 × 10−7
rs75916004 11 101,896,887   A/G CAC > =10 vs. CAC < 10 Dominant 0.22 0.04 1.2 × 10−6 0.21 0.09 1.5 × 10−2 5.9 × 10−8
rs77934287 12 23,224,253 AK094733 A/G CAC > =10 vs. CAC < 10 Recessive −0.38 0.10 3.0 × 10−4 −0.59 0.16 1.8 × 10−4 4.8 × 10−7
rs448792 13 32,677,424 FRY T/C CAC > =10 vs. CAC < 10 Dominant 0.21 0.05 2.3 × 10−5 0.21 0.08 8.4 × 10−3 ++ 6.1 × 10−7
rs77757620 15 42,953,597 STARD9 T/C CAC > =10 vs. CAC < 10 Additive 0.15 0.04 5.0 × 10−5 0.18 0.06 2.3 × 10−3 ++ 4.3 × 10−7
rs13331874 16 581,733 SOLH A/G CAC > =10 vs. CAC < 10 Recessive −0.28 0.06 1.6 × 10−6 −0.29 0.11 1.2 × 10−2 ++ 6.3 × 10−8
rs4459623 18 28,798,433 DSC1 C/G CAC > =10 vs. CAC < 10 Recessive −0.32 0.09 4.1 × 10−4 −0.55 0.13 4.3 × 10−5 ++ 5.3 × 10−7
  1. CHR chromosome, MOI Mode of Inheritance, DE Direction of effect (+: positive association, −: negative association)
  2. *Upstream to ABCB1
  3. aResults observed with the 90 HU CAC
  4. bResults observed with the 130 HU CAC