Table 4 Top ten targeter miRNAs for Human (that are connected with maximum number of gene-modules and that target maximum number genes from the connected modules) with information of their maximum number of targeted genes as well as gene-modules, and verified information of them
Sl. No. | MiRNAs | Number of connected gene-modules | Number of targeted genes | Name of the connected gene-modules (number of targeted genes in the modules) | Disease and Disease-verified information of miRNAs | Status of miRNAs |
|---|---|---|---|---|---|---|
1 | hsa-miR-579 | 4 | 17 | Blue (2), Brown (2), Green (1), Turquoise (12). | Alzheimer’s Disease [38] | Known |
2 | hsa-miR-495 | 4 | 14 | Blue (5), Brown (2), Green (1), Turquoise (6). | HIV mediated dementia [39] | Known |
3 | hsa-miR-27b-3p-3p | 4 | 10 | Blue (5), Brown (1), Green (1), Turquoise (3). | Presence in high intensity for Alzheimer’s disease [74] | Known |
4 | hsa-miR-449b-5p-5p | 4 | 10 | Blue (1), Brown (2), Green (1), Turquoise (6). | Presence in low intensity in case of Alzheimer’s disease | Known |
5 | hsa-miR-34a | 4 | 10 | Blue (1), Brown (2), Green (1), Turquoise (6). | neuropsychaitric and nuerodegenrative diseases [40] | Known |
6 | hsa-miR-34c-5p | 4 | 10 | Blue (1), Brown (2), Green (1), Turquoise (6). | Bipolar disorder and Schizophenia [41] | Known |
7 | hsa-miR-449a | 4 | 10 | Blue (1), Brown (2), Green (1), Turquoise (6). | Molecular Targets for Neurodegenerative Diseases [42] | Known |
8 | hsa-miR-607 | 4 | 9 | Blue (3), Brown (3), Green (1), Turquoise (2). | Neurodegenerative diseases [43] | Known |
9 | hsa-miR-27a-3p | 4 | 9 | Blue (4), Brown (1), Green (1), Turquoise (3). | Alzheimer’s Disease [75] | Known |
10 | hsa-miR-664-3p | 4 | 9 | Blue (2), Brown (2), Green (1), Turquoise (4). | Psychiatric and Neurodegenerative disease [44]. | Known |