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Table 3 The spectrum of HBB gene mutations in the regional hot-spot of South Asia and Southeast Asia

From: High resolution melting curve analysis targeting the HBB gene mutational hot-spot offers a reliable screening approach for all common as well as most of the rare beta-globin gene mutations in Bangladesh

Sl No. Countries Mutations Percentage References
1 Bangladesh c.79G > A, c.92 + 5 G > C, c.126_129delCTTT, c.92 G > C, c.27_28insG, c.47G > A, c.92 G > A, c.46delT, c.92 + 130 G > C, and c.51delC >95% [13, 14]
2 India: West Bengal, Uttar Pradesh, Eastern India, Southern India c.92 + 5 G > C, c.92 + 1G > C, c.27_28insG, c.47G > A, c.51delC, c.92 + 5 G > C, c.126_129delCTTT > 90% [23]
3 Sri Lanka c.92 + 5 G > C, c.92 + 1G > C, c.79G > A, c.92 G > C, c.27_28insG, c.47G > A, c.51delC, c.126_129delCTTT >90% [24]
4 Malaysia c.92 + 5 G > C, c.92 + 1 G > C, c.59A > G, c.126_129delCTTT, c.52A > T, c.27_28insG, c.216_217insA, c.92 + 1 G > C, c.79G > A >90% [25]
5 Thailand c.126_129delCTTT, c.52A > T, c.59A > G, c.27_28insG, c.92 + 1 G > C, c.92 + 5 G > C, c.108C > A, c.47G > A >83% [26]
6 Pakistan c.92 + 5 G > C, c.27_28insG, c.92 + 1G > C, c.126_129delCTTT, c.92 G > A, c.17_18delCT and c.47G > A >82% [27]
7 Mayanmar c.92 + 1 G > T, c.126_129delCTTT, c.92 + 5 G > C, c.53A > T, c.135delC, c.108C > A, c.47G > A, c.51delC, c.46delT, c.92 + 1 G > C, c.27_28insG, c.126delC >80% [28]