Fig. 3
From: Vps4b heterozygous mice do not develop tooth defects that replicate human dentin dysplasia I
Expression of VPS4B in mouse teeth and stereomicroscopy of mouse teeth. A, B, and C Representative 1-, 3-, and, 6-month-old mouse teeth, respectively. Strong VPS4B signals (brown) were observed in the odontoblasts of WT mice (a, b, and c), whereas heterozygous mice (d, e, and f) displayed markedly reduced signals. The red arrows indicate the odontoblast cell layer and the black arrow indicates the pits and fissures of teeth at the occlusal surface. Abbreviations: de, dentin; p, pulp; od, odontoblast (a, b, c, g, h, and i are WT mice; d, e, f, j, k, and l are HET mutant mice)