Table 5 Spike glycoprotein PRRA-like insertions from SARS-CoV-2 isolates

N-terminal domain

P26

IEKN

UFA95489

1

V62

TSGNN

QZQ09947

1

S71

HLKD

UEP74721

1

T76

AVMSL

UEV78566

1

T109

ILWW

UHT93004

1

N185

MQAVS

UWL01218

1

SARW

UYR39941

1

F186

TPAGG

WCF88733

1

I210

KKGA

UWJ32324

1

RHAVLSG

WDD77904

1

L212

FMAE

UPH02236, UPH02715, UPL60987, UPL79201, UPL83322, UPL97779, UPS43182, UPW23099, UPW23870, UZZ69309, URP81062, URP81074, URP81794, URG88035, UQE96806, UQE28102

16

TVGG

UPQ93706, UPQ95992, UYL90137, UYL90173, UPN04511, UQR90517, UQR92623, UQS02680, UQS06834, UQS05613, UQE37288

11

NLTI

WED35345

1

REPEDR

UJS73581

1

R214

ASPN

UIS34449

1

DQAF

UAB38160

1

EPEDN

UIG18418

1

R246

SEIE

QTQ48337

1

TLRA

WCL14692, WBE99745, WBG79084

3

S247

LRAG

WBG79084, WCC34642, WBY86968, WBT65812

4

SKWL

WCP01579, WDG34661, OQ439587, OQ673691, OQ445194, OQ458267, OQ193613

7

SRWM

ZK92183, WAD73656, WAD78937, WAD79819,…. (see Table S1)

331

SVGS

WCZ87602, OQ431694

1

YGHT

ULC27716

1

YHSD

UXM33786

1

YRSCCIQ

ULP78342

1

Y248

AGTG

UQW64543

1

HSDR

UXV06186

1

KWLD

WGI99683

1

RWMD

WGL43195

1

L296

HGHTF

UHG56576

1

T299

AVPY

UHJ33999

1

Receptor binding domain

R457

HYKYF

QVM41426

1

V483

EVQF

UKF78016

1

V551

EIPTS

UEZ97007, UFA03190, UEF49231

3

Furin cleavage site (S1/S2 junction)

S673

YSLS

QVL88657, QVL88693

2

T678

TQRA

WCJ55381

1

N679

GIAL

QSX93802

1

KAVR

QTC70411

1

S1/S2 region

S698

LHHV

UVT41921

1

A701

GTNA

UPA68498

1

E702

CGPKKST

UNH71219

1

LSSTE

UUH48256

1

SLSSTA

UTV73082

1

N703

YSLSS

UWQ86862

1

S704

WCWL

URN60119

1

V705

GNICYT

UXB43176

1

N710

KPCNGVAG

UTH52964

1

N717

SHVV

UJT69381

1

S730

TNVS

UNW19168

1

Heptad repeat 2

D1165

WLSR

URF73848

1

D1168

ISGIDLGD

UHY88495

1