Table 1 List of DEGs identified from analysis of DEGs and their known functions. Information on gene symbols and names from [30], information on gene functions downloaded from [31] and then edited

Il12b

Interleukin 12B

The encoded protein contributes to cytokine activity and cytokine receptor binding activity. It is involved in the regulation of T cell mediated cytotoxicity, T-helper 1 type immune response, and acts in the defense response to other organisms, including cellular responses to lipopolysaccharide, and regulation of type II interferon production.

Trim30d

Tripartite motif-containing 30D

The encoded protein has transcription co-activator activity and ubiquitin protein ligase activity. It acts as a defense response to other organisms.

Ifi207

Interferon activated gene 207

The encoded protein has double-stranded DNA binding activity and is predicted to be involved in the activation of the innate immune response and the cellular response to interferon-beta.

Mx2

MX dynamin-like GTPase 2

The encoded protein has GTP-binding activity and GTPase activity. It is involved in the negative regulation of viral genome replication and the response to type I interferon.

Ifi204

Interferon activated gene 204

The encoded protein has double-stranded DNA binding activity and transcription coregulator activity and is involved in cellular response to interferon-alpha. It acts in cellular responses to interferon-beta, positive regulation of osteoblast differentiation, and regulation of transcription by RNA polymerase II.

Ifnb1

Interferon beta 1

The encoded protein has cytokine activity and type I interferon receptor binding activity. It is involved in the response to viruses and the type I interferon-mediated signaling pathway.

Oas1a

2’-5’ oligoadenylate synthetase 1 A

The encoded protein has 2’-5’-oligoadenylate synthetase activity and double-stranded RNA binding activity. It is involved in the purine nucleotide biosynthetic process and acts upstream of the negative regulation of the viral process.

Ifi203

Interferon activated gene 203

The encoded protein has double-stranded DNA binding activity and protein binding activity. It acts upstream of or within the cellular response to interferon-beta.

Xaf1

XIAP associated factor 1

The encoded protein has molecular sequestering activity. It is predicted to be involved in negative regulation of protein-containing complex assembly, negative regulation of type I interferon production, and response to interferon-beta. It is thought to act upstream of apoptotic processes.

Tgtp2

T cell specific GTPase 2

The encoded protein has GTPase activity. It is predicted to be involved in the defense response to protozoan.

C3ar1

Complement component 3a receptor 1

The encoded protein has G protein-coupled receptor activity, complement component C3a binding activity, and complement receptor activity. It is involved in the regulation of angiogenesis, vascular endothelial growth factor production, and granulocyte chemotaxis.

Ccl1

C-C motif chemokine ligand 1

The encoded protein has cytokine activity. It is involved in the cellular response to interleukin-17 and acts on cell chemotaxis.

Thbs1

Thrombospondin 1

The encoded protein has extracellular matrix-binding activity. It is involved in behavioral responses to pain, regulation of macrophage chemotaxis, and regulation of the transforming growth factor beta receptor signaling pathway. It acts in the cellular response to nitric oxide, circulatory system development, and monocyte aggregation.

Serpine1

Serine (or cysteine) peptidase inhibitor, clade E, member 1

The encoded protein has serine-type endopeptidase inhibitor activity. It is involved in the defense response to Gram-negative bacteria, the negative regulation of plasminogen activation, and the regulation of angiogenesis. It acts in cellular responses to the transforming growth factor beta stimulus, placenta development, and regulation of angiogenesis.

Cxcl11

Chemokine (C-X-C motif) ligand 11

The encoded protein has CXCR3 chemokine receptor binding activity, chemokine activity, and heparin binding activity. It is involved in the cellular response to lipopolysaccharide, leukocyte chemotaxis, and positive regulation of the release of sequestered calcium ion into the cytosol. It acts on cell chemotaxis and signal transduction.

Cdt1

Chromatin licensing and DNA replication factor 1

The encoded protein enables DNA binding. Ii is involved in DNA replication checkpoint signaling and regulation of DNA-templated DNA replication initiation, acting upstream of regulation of nuclear cell cycle DNA replication.

Ccne1

Cyclin E1

The encoded protein has cyclin-dependent protein serine/threonine kinase regulator, kinase, and protein kinase binding activity. It acts in DNA metabolic process, homologous chromosome pairing at meiosis, and negative regulation of transcription by RNA polymerase II.

Psrc1

Proline/serine-rich coiled-coil 1

The encoded protein has microtubule binding activity. It is involved in microtubule bundle formation, negative regulation of cell growth, and positive regulation of microtubule polymerization.

Fen1

Flap structure specific endonuclease 1

The encoded protein has DNA binding, metal ion binding, and nuclease activity. It is involved in DNA repair and DNA replication.

Eme1

Essential meiotic structure-specific endonuclease 1

The encoded protein has DNA binding activity. It is predicted to contribute to crossover junction DNA endonuclease activity, to be involved in DNA metabolic process and mitotic intra-S DNA damage checkpoint signaling. It is part of heterochromatin.

Fcna

Ficolin A

The encoded protein enables antigen binding. It has carbohydrate derivative binding and signaling receptor binding activity. It is predicted to be involved in complement activation, lectin pathway.

Hc

Hemolytic complement

The encoded protein has endopeptidase inhibitor activity. It is involved in positive regulation of angiogenesis and acts upstream in glomerulus development, inflammatory response to wounding, and neutrophil homeostasis.

Megf10

Multiple EGF-like-domains 10

The encoded protein has Notch binding activity and is involved in myoblast development, positive regulation of myoblast proliferation, and skeletal muscle satellite cell proliferation. It acts in apoptotic process involved in development, engulfment of apoptotic cell, and recognition of apoptotic cell.

Cntn2

Contactin 2

The encoded protein enables cell-cell adhesion mediator activity. It is involved in clustering of voltage-gated potassium channels, establishment of protein localization to juxtaparanode region of axon, and reduction of food intake in response to dietary excess.

Spon2

Spondin 2, extracellular matrix protein

The encoded protein enables antigen binding and lipopolysaccharide binding activity. It acts in the defense response to other organism, opsonization, and positive regulation of cytokine production.

Sftpd

Surfactant associated protein D

The encoded protein has protein binding activity and is predicted to be involved in negative regulation of interleukin-2 production, opsonization, and regulation of phagocytosis. It acts in innate immune response and respiratory gaseous exchange by respiratory system.

Cntn6

Contactin 6

The encoded protein enables cell-cell adhesion mediator activity and acts in positive regulation of Notch signaling pathway.

Nts

Neurotensin

The encoded protein has neuropeptide receptor binding activity and receptor ligand activity. It is predicted to be involved antimicrobial humoral immune response mediated by antimicrobial peptide, neuropeptide signaling pathway, and visual learning.

Ccl17

C-C motif chemokine ligand 17

The encoded protein has CCR4 chemokine receptor binding activity and chemokine activity and acts in negative regulation of myoblast differentiation.

Pgc

Progastricsin (pepsinogen C)

The encoded protein has aspartic-type endopeptidase activity. It is predicted to be involved in positive regulation of antibacterial peptide production and proteolysis.