Skip to main content

Advertisement

Table 1 Ocular abnormalities in various strains

From: Intraocular pressure in genetically distinct mice: an update and strain survey

Strain Clinical phenotype Mouse incidence Eye Incidence Comments
SB/Le Oculocutaneous albinism with iris transillumination 17/17 34/34 Chediak-Higashi syndrome caused by the beige mutation [80]
C57/LJ Iris transillumination 5/17 7/34 Incidence increased with age, iris atrophy sometimes evident at
     20 months
BUB/BnJ Anterior subcapsular and cortical cataracts 2/8 2/16 Incidence in independent 3 to 4 month old mice was 9/12 mice
     17/24 eyes
AKR/J Irregular pupil 3/8 5/16  
LP/J Cortical cataract 5/10 10/20  
RIII/SJ Lens extrusion cataract 8/12 16/24  
NZB/BiNJ Cortical cataract 7/14 10/28  
  1. All strains shown in Figure 1 were evaluated but only strains with abnormalities are shown. For incidence, the numerator indicates the number of mice or eyes affected and the denominator indicates the total number analyzed. The mice were 6 to 12 months old at the time of analysis and were not studied at other ages unless indicated. Histological analysis confirmed these observations and also identified calcified cyst like structures in the iris epithelium of strains SB/Le and SEC/1ReJ. A low incidence of corneal scarring was noted in some strains and likely resulted from a scratched cornea. Previously described retinal degeneration [[81]] caused by homozygosity for the Pde6brd 1mutation was noted in strains SB/Le, ST/bJ, BUB/BnJ, CBA/J, C3H/HeJ, SJL/J and SWR/J.