Table 1 Effect of each polymorphic SNP on each of the cognitive outcomes, controlling for sex and age 11 cognitive ability.

AGER

rs3134943

.770

.808

.058

.773

rs1800684

.701

.738

.036

.773

APOD

rs6786696

.982

.930

.680

.807

rs17033096

.748

.683

.527

.610

rs4686327

.580

.959

.761

.419

APP

rs1787439

.817

.409

.065

.112

rs2040276

.094

.725

.108

.246

rs2026225

.736

.818

.770

.142

rs2830019

.948

.443

.809

.106

rs2830020

.948

.443

.809

.106

rs2830038

.284

.636

.076

.075

rs1041420

.022

.346

.389

.148

rs2830045

.463

.366

.398

.669

rs2830048

.247

.789

.233

.052

rs2830052

.016

.051

.932

.405

rs3787650

.669

.667

.871

.823

rs2830071

.474

.903

.469

.119

rs2830102

.003

.016

.978

.436

BACE

rs535860

.994

.777

.416

.610

rs638405

.541

.184

.985

.359

CAT

rs769217

.304

.804

.121

.921

CBS

rs234706

.149

.299

.846

.676

CDKN1B

rs3093728

.677

.767

.286

.263

rs34330

.088

.522

.413

.034

rs4251698

.632

.589

.439

.328

rs7330

.901

.782

.231

.880

CHRM2

rs8191992 associated with IQ [60].

.156

.610

.796

.781

CP

rs16861582

.020

.228

.728

.318

rs1053709

.684

.682

.667

.606

rs6799507

.770

.859

.061

.854

rs701753

.576

.325

.157

.682

rs17838831

.155

.103

.786

.027

CRYAB

rs4252581

.376

.683

.243

.789

rs14133

.931

.546

.696

.552

rs4252583

.097

.010

.394

.184

rs762550

.344

.713

.622

.073

CSNK1D

rs6416862

.338

.506

.010

.814

CTSD

rs17571 associated with AD [61] and general intelligence [62].

.355

.402

.958

.333

CTSH

rs13345

.312

.964

.118

.589

rs12148472

.700

.944

.318

.406

rs1036938

.835

.509

.131

.916

CTSS

rs10888390

.322

.557

.259

.127

CTSZ

rs9760

.623

.387

.011

.082

DNAJB1

rs3962158

.081

.295

.216

.716

DNAJB2

rs2276638

.283

.639

.794

.321

rs3731897

.287

.546

.793

.383

FOSB

rs2282695

.661

.938

.317

.762

rs2238686

.073

.036

.676

.849

FOXO3A

rs12202049

.851

.557

.782

.933

rs2883881

.831

.952

.250

.098

rs17532874

.814

.848

.475

.510

rs12203787

.887

.473

.842

.892

GCLC

rs1555903

.659

.336

.420

.295

GFAP

rs3744473

.620

.275

.362

.674

rs3744470

.782

.716

.890

.420

rs9916491

.620

.275

.362

.674

rs1126642

.669

.187

.295

.321

GLRX

rs4561

.254

.560

.182

.003

GPX1

rs3448

.731

.135

.660

.464

GSR

rs2251780

.232

.664

.788

.860

GSS

rs6119545

.019

.029

.073

.299

rs7265992

.238

.412

.193

.619

rs2025096

.999

.897

.963

.614

GSTA2

rs6577

.683

.052

.908

.492

rs2180314

.662

.116

.395

.500

GSTA4

rs1802061

.268

.810

.365

.982

GSTA5

rs2397118

.599

.960

.763

.677

GSTM3

rs7483

.722

.926

.736

.488

GSTM4

rs560018

.747

.619

.842

.773

rs650985

.763

.756

.686

.717

GSTO1

s4925

.344

.971

.847

.119

GSTO2

rs156697

.619

.726

.405

.028

rs3758572

.670

.553

.407

.754

GSTP1

rs762803

.258

.969

.712

.688

rs947894

.206

.302

.745

.395

rs1799811

.436

.528

.110

.171

rs1871042

.269

.500

.987

.461

GSTT2

rs140188

.266

.382

.070

.297

GSTZ1

rs2270421

.072

.203

.178

.847

rs2287395

.159

.288

.174

.667

rs3177429

.245

.507

.533

.737

rs2287396

.267

.083

.884

.268

rs1046428

.312

.511

.191

.663

HMOX2

rs6500610

.635

.364

.275

.215

rs11643057

.733

.411

.666

.363

rs17137094

.010

.011

.189

.675

HSPA12A

rs1665659

.443

.454

.067

.362

rs4752003

.030

.010

.619

.689

rs1665638

.783

.645

.270

.293

rs740599

.585

.630

.865

.758

rs1900501

.247

.025

.435

.190

HSPA12B

rs3827077

.121

.689

.473

.190

rs6076550

.493

.505

.828

.870

rs2295340

.516

.725

.462

.612

HSPA1L

rs2075800

.133

.371

.267

.845

HSPA2

rs17101915

.493

.583

.051

.249

rs11848114

.251

.615

.109

.110

HSPA4

rs398606

.680

.021

.216

.775

rs14355

.096

.062

.716

.246

HSPA5

rs430397

.348

.413

.084

.825

HSPA8

rs3763897

.349

.020

.119

.960

HSPA9B

rs10117

.006

.211

.261

.267

HTR2A

rs3803189

.128

.118

.984

.910

rs6314 associated with episodic memory [63].

.096

.180

.429

.388

rs1923884

.966

.601

.948

.773

rs6305

.151

.746

.926

.133

rs6313 associated with AD [64].

.209

.079

.996

.885

IDE

rs7895832

.181

.093

.690

.470

rs3758505 associated with AD [65].

.181

.093

.690

.470

IL1B

rs1143634 associated with AD [66].

.372

.082

.738

.450

rs16062

.508

.404

.711

.484

rs1143627

.591

.872

.354

.926

LTF

rs4683233

.220

.073

.826

.023

MPO

rs2759

.500

.154

.634

.301

rs7208693

.959

.940

.782

.945

MSRA

rs12679328

.950

.072

.466

.063

rs3735823

.985

.087

.833

.245

rs814422

.237

.111

.462

.584

rs1994224

.460

.078

.592

.414

rs6601414

.034

.386

.211

.717

rs17151140

.396

.191

.876

.567

rs1484645

.609

.343

.252

.039

rs6986977

.510

.907

.764

.261

rs877390

.661

.389

.544

.690

rs7845503

.437

.936

.722

.020

rs6992349

.956

.718

.292

.573

rs4288376

.189

.373

.503

.250

rs10503405

.965

.353

.263

.871

rs6983870

.271

.246

.432

.265

rs4260895

.263

.069

.341

.154

rs2952182

.355

.612

.586

.832

rs11783821

.437

.523

.149

.586

rs17151588

.204

.360

.309

.214

rs7832708

.233

.151

.899

.021

rs4841322

.746

.663

.882

.400

rs4841324

.706

.644

.849

.435

MSRB2

rs10764383

.951

.540

.043

.272

rs11013295

.862

.668

.404

.354

rs7427

.006

.111

.487

.550

NDRG1

rs2977499

.536

.626

.436

.829

rs2272653

.970

.517

.812

.184

rs2930002

.961

.599

.502

.543

NDUFA10

rs2083411

.594

.085

.809

.255

NDUFA3

rs254259

.021

.020

.517

.269

NDUFA6

rs1801311

.630

.207

.074

.036

NDUFA7

rs561

.417

.734

.077

.754

rs2241591

.239

.180

.366

.774

NDUFA8

rs4147659

.180

.585

.584

.574

rs6822

.238

.634

.690

.646

rs4679

.079

.592

.405

.389

NDUFA9

rs4147672

.611

.387

.825

.723

rs4147682

.611

.387

.825

.723

NDUFAB1

rs459894

.620

.580

.948

.070

NDUFAF1

rs3204853

.294

.162

.506

.566

NDUFB10

rs2302175

.129

.533

.878

.373

NDUFB5

rs2339844

.590

.320

.894

.083

NDUFB7

rs9543

.676

.552

.081

.032

NDUFB8

rs1800662

.354

.447

.709

.738

NDUFB9

rs11547284

.483

.023

.690

.840

NDUFS1

rs11548670

.166

.258

.002

.287

rs4147707

.977

.610

.613

.993

NDUFS2

rs3813624

.225

.973

.255

.783

rs16832694

.490

.890

.878

.229

rs16832699

.225

.973

.255

.783

rs11587213

.957

.200

.293

.925

NDUFS4

rs4147732

.727

.369

.422

.516

rs2279516

.710

.876

.073

.240

rs13156337

.417

.608

.468

.075

rs31304

.451

.409

.938

.341

rs31303

.783

.260

.609

.885

rs567

.688

.190

.226

.641

NDUFS6

rs3776141

.329

.561

.117

.011

NDUFV2

rs906807

.346

.009

.892

.732

NDUFV3

rs4148973

.718

.473

.0003

.559

rs8128440

.710

.500

.0002

.742

NOS1

rs9658501

.278

.275

.696

.799

rs3741475

.556

.447

.469

.212

rs10774909

.393

.138

.533

.338

rs9658446

.062

.186

.249

.004

rs2293054

.443

.289

.893

.718

rs11612772

.659

.255

.253

.737

rs561712

.795

.719

.870

.628

rs9658256

.661

.270

.405

.089

NOS2A

rs2297512

.187

.471

.553

.164

rs2297518

.504

.285

.556

.254

rs1137933

.455

.429

.206

.428

rs3730017

.318

.955

.342

.373

NOS3

rs1549758

.179

.489

.620

.463

rs1799983 associated with mild cognitive impairment [67].

.380

.263

.779

.258

rs2566514

.738

.774

.876

.298

rs3918232

.612

.092

.226

.546

NR2C2

rs17536979

.480

.367

.719

.206

rs648912

.957

.489

.849

.358

PLAU

rs2227564 associated with AD [68].

.766

.877

.796

.623

rs2227567

.121

.816

.508

.440

rs2227568

.974

.696

.053

.886

rs4065

.459

.953

.120

.293

PON2

rs6954345

.054

.261

.510

.788

rs10487133

.294

.661

.510

.686

rs11545941

.054

.261

.510

.788

rs17166875

.054

.261

.510

.788

PRDX1

rs6667191

.912

.697

.763

.689

PRDX2

rs10413408

.824

.251

.445

.773

rs10422248

.824

.251

.445

.773

PRDX4*

rs552105 (male)

.611

.942

.495

.509

rs552105 (female)

.856

.569

.894

.898

rs1548734 (male)

.611

.942

.495

.509

rs1548734 (female)

.832

.515

.891

.870

SAA2

rs2468844

.558

.557

.676

.596

SEPP1

rs6413428

.073

.055

.948

.307

rs7579

.616

.677

.851

.786

SIRT1

rs2273773

.967

.517

.358

.730

rs2234975

.937

.840

.454

.750

SLC25A27

rs9369628

.383

.213

.990

.646

rs12192544

.881

.251

.989

.739

rs3757241

.126

.975

.304

.739

SOD2

rs1799725

.381

.937

.438

.111

SOD3

rs1799895

.485

.813

.745

.924

TF

rs1130459

.153

.069

.260

.311

rs1799852

.685

.237

.149

.919

rs1799899

.789

.722

.454

.835

rs1049296

.434

.899

.829

.621

rs3811656

.087

.025

.248

.796

TXN

rs4135162

.157

.747

.929

.289

TXN2

rs2281082

.951

.220

.864

.253

TXNRD1

rs11111979

.755

.026

.399

.709

rs7134193

.850

.101

.314

.737

rs4964287

.924

.205

.035

.615

TXNRD2

rs3827288

.585

.211

.136

.471

rs5992495

.879

.865

.209

.056

rs5748469

.577

.780

.232

.832

rs5746847

.388

.983

.125

.691

TXNRD3

rs777241

.993

.767

.270

.498

UCP2

rs660339

.578

.723

.520

.372

VEGF

rs2010963

.980

.766

.372

.228

rs833068

.974

.765

.434

.205

rs3025000

.849

.828

.408

.227

rs3025010

.192

.935

.267

.161

rs3025039

.112

.130

.882

.230

rs3025053

.487

.326

.705

.620

VIM

rs1049341

.336

.976

.815

.887